# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3383932 | F | Induction of hypnotic activity in iv dosed Sprague-Dawley rat assessed as loss of righting reflex | Rattus norvegicus | 36 | ALA3351378 | organism-based format | Scientific Literature | |
2. | ALA3383933 | T | Toxicity in Sprague-Dawley rat assessed as motor coordination by rotarod test | Rattus norvegicus | 36 | ALA3351378 | organism-based format | Scientific Literature | |
3. | ALA3384495 | A | Therapeutic index, ratio of LC50 for Sprague-Dawley rat by rotarod test to HD50 for hypnotic activity in iv dosed Sprague-Dawley rat | 36 | ALA3351378 | organism-based format | Scientific Literature | ||
4. | ALA3384496 | F | Induction of hypnotic activity in iv dosed Sprague-Dawley rat assessed as time duration of loss of righting reflex | Rattus norvegicus | 36 | ALA3351378 | organism-based format | Scientific Literature | |
5. | ALA3384498 | F | Induction of hypnotic activity in iv dosed Sprague-Dawley rat assessed as reflex depression 10 secs following injection | Rattus norvegicus | 3 | ALA3351378 | organism-based format | Scientific Literature | |
6. | ALA3384499 | F | Induction of hypnotic activity in iv dosed Sprague-Dawley rat assessed as reflex depression 20 secs following injection | Rattus norvegicus | 3 | ALA3351378 | organism-based format | Scientific Literature | |
7. | ALA3378417 | P | Octanol-buffer partition coefficient, log P of the compound by HPLC | 35 | ALA3351378 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA3378418 | B | Displacement of [3H]EBOB from GABAA receptor in Sprague-Dawley rat frontoparietal cortex membrane at 50 umol by liquid scintillation counting | Rattus norvegicus | 35 | ALA3351378 | assay format | Scientific Literature | |
9. | ALA3378419 | B | Displacement of [3H]MK801 from NMDA receptor in Sprague-Dawley rat cerebral cortex membrane at 50 umol by liquid scintillation counting | Rattus norvegicus | 35 | ALA3351378 | tissue-based format | Scientific Literature | |
10. | ALA5133317 | P | Lipophilicity, logP of the compound | 20 | ALA5131414 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA5133318 | F | Anesthetic activity in mouse assessed as concentration required to induce hypnotic effect | Mus musculus | 20 | ALA5131414 | organism-based format | Scientific Literature | |
12. | ALA5133319 | T | Toxicity in mouse assessed as lethal dose | Mus musculus | 20 | ALA5131414 | assay format | Scientific Literature | |
13. | ALA5133320 | T | Therapeutic index, ratio of LD50 for toxicity in mouse to HD50 for anesthetic activity in mouse | 20 | ALA5131414 | organism-based format | Scientific Literature | ||
14. | ALA5133321 | F | Anesthetic activity in mouse assessed as onset time | Mus musculus | 4 | ALA5131414 | organism-based format | Scientific Literature | |
15. | ALA5133322 | F | Anesthetic activity in mouse assessed as time duration of loss of righting reflex | Mus musculus | 4 | ALA5131414 | organism-based format | Scientific Literature | |
16. | ALA5133323 | F | Anesthetic activity in mouse assessed as time to walk at 2 times of HD50 concentration | Mus musculus | 4 | ALA5131414 | organism-based format | Scientific Literature | |
17. | ALA5133324 | F | Anesthetic activity in rat assessed as concentration required to induce hypnotic effect | Rattus norvegicus | 3 | ALA5131414 | organism-based format | Scientific Literature | |
18. | ALA5133325 | T | Toxicity in rat assessed as lethal dose | Rattus norvegicus | 3 | ALA5131414 | assay format | Scientific Literature | |
19. | ALA5133326 | T | Therapeutic index, ratio of LD50 for toxicity in rat to HD50 for anesthetic activity in rat | 3 | ALA5131414 | assay format | Scientific Literature | ||
20. | ALA5133327 | F | Anesthetic activity in rabbit assessed as concentration required to induce hypnotic effect | Oryctolagus cuniculus | 3 | ALA5131414 | organism-based format | Scientific Literature |