# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3377654 | B | Inhibition of BACE1 (unknown origin) incubated for 60 mins prior to substrate addition measured after 60 mins by fluorescence assay | Homo sapiens | 18 | ALA3352228 | single protein format | Scientific Literature | |
2. | ALA3377655 | B | Inhibition of BACE1 in HEK293 cells assessed as Abeta40 level after overnight incubation by sandwich ELISA | Homo sapiens | 18 | ALA3352228 | cell-based format | Scientific Literature | |
3. | ALA3377656 | B | Inhibition of human ERG channel expressed in HEK293 cells assessed as [3H]-dofetilide binding after 90 mins by liquid scintillation counting analysis | Homo sapiens | 18 | ALA3352228 | cell-based format | Scientific Literature | |
4. | ALA3377657 | A | Apparent permeability across wild type pig LLC-PK1 cells after 2 hrs by LC-MS/MS analysis | Sus scrofa | 18 | ALA3352228 | cell-based format | Scientific Literature | |
5. | ALA3377658 | A | Efflux ratio of permeability from basolateral to apical over apical to basolateral side in pig LLC-PK1 cells transfected with human MDR1 after 2 hrs by LC-MS/MS analysis | Sus scrofa | 18 | ALA3352228 | cell-based format | Scientific Literature | |
6. | ALA3377659 | A | Efflux ratio of permeability from basolateral to apical over apical to basolateral side in pig LLC-PK1 cells transfected with rat MDR1a after 2 hrs by LC-MS/MS analysis | Sus scrofa | 18 | ALA3352228 | cell-based format | Scientific Literature | |
7. | ALA3377660 | A | Clearance in human liver microsomes at 1 uM after 30 mins | Homo sapiens | 18 | ALA3352228 | assay format | Scientific Literature | |
8. | ALA3377661 | A | Clearance in rat liver microsomes at 1 uM after 30 mins | Rattus norvegicus | 18 | ALA3352228 | assay format | Scientific Literature | |
9. | ALA3371633 | P | Lipophilicity, log P of the compound | 2 | ALA3352228 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA3371637 | B | Inhibition of BACE2 (unknown origin) | Homo sapiens | 2 | ALA3352228 | single protein format | Scientific Literature | |
11. | ALA3371638 | B | Inhibition of renin (unknown origin) | Homo sapiens | 2 | ALA3352228 | single protein format | Scientific Literature | |
12. | ALA3371639 | B | Inhibition of pepsin (unknown origin) | Homo sapiens | 2 | ALA3352228 | assay format | Scientific Literature | |
13. | ALA3371640 | B | Inhibition of cathepsin D (unknown origin) | Homo sapiens | 2 | ALA3352228 | single protein format | Scientific Literature | |
14. | ALA3371641 | B | Inhibition of cathepsin E (unknown origin) | Homo sapiens | 2 | ALA3352228 | single protein format | Scientific Literature | |
15. | ALA3371642 | B | Selectivity ratio of IC50 for BACE2 (unknown origin) to IC50 for BACE1 (unknown origin) | Homo sapiens | 2 | ALA3352228 | assay format | Scientific Literature | |
16. | ALA3371643 | B | Selectivity ratio of IC50 for renin (unknown origin) to IC50 for BACE1 (unknown origin) | Homo sapiens | 2 | ALA3352228 | assay format | Scientific Literature | |
17. | ALA3371644 | B | Selectivity ratio of IC50 for pepsin (unknown origin) to IC50 for BACE1 (unknown origin) | Homo sapiens | 2 | ALA3352228 | assay format | Scientific Literature | |
18. | ALA3371645 | B | Selectivity ratio of IC50 for cathepsin D (unknown origin) to IC50 for BACE1 (unknown origin) | Homo sapiens | 2 | ALA3352228 | assay format | Scientific Literature | |
19. | ALA3371646 | B | Selectivity ratio of IC50 for cathepsin E (unknown origin) to IC50 for BACE1 (unknown origin) | Homo sapiens | 2 | ALA3352228 | assay format | Scientific Literature | |
20. | ALA3371674 | B | Inhibition of BACE1 (unknown origin) assessed as enhancement of fluorescence intensity | Homo sapiens | 29 | ALA3351923 | single protein format | Scientific Literature |