Ratio of 1alpha,25-(OH)2D3 ED50 to compound ED50 for VDR-mediated 24-hydroxylase gene expression in rat ROS 17/2.8 cells after 16 hrs by luciferase reporter assay
Effect on bone calcium mobilization in weanling Sprague-Dawley rat assessed as serum calcium level at 87 pmol/day, ip administered as 4 consecutive daily doses measured 24 hrs after last dose (Rvb = 4.2 to 4.9 mg/dL)
Effect on bone calcium mobilization in weanling Sprague-Dawley rat assessed as serum calcium level at 780 pmol/day, ip administered as 4 consecutive daily doses measured 24 hrs after last dose (Rvb = 4.2 to 4.9 mg/dL)
Effect on bone calcium mobilization in weanling Sprague-Dawley rat assessed as serum calcium level at 7020 pmol/day, ip administered as 4 consecutive daily doses measured 24 hrs after last dose (Rvb = 4.2 to 4.9 mg/dL)
Effect on intestinal calcium transport in weanling Sprague-Dawley rat assessed as increase in ratio of serosal to mucosal calcium level at 780 pmol/day, ip administered as 4 consecutive daily doses measured 24 hrs after last dose
Effect on intestinal calcium transport in weanling Sprague-Dawley rat assessed as increase in ratio of serosal to mucosal calcium level at 87 pmol/day, ip administered as 4 consecutive daily doses measured 24 hrs after last dose
Effect on intestinal calcium transport in weanling Sprague-Dawley rat assessed as increase in ratio of serosal to mucosal calcium level at 7020 pmol/day, ip administered as 4 consecutive daily doses measured 24 hrs after last dose
Effect on intestinal calcium transport in weanling Sprague-Dawley rat assessed as increase in ratio of serosal to mucosal calcium level at 35100 pmol/day, ip administered as 4 consecutive daily doses measured 24 hrs after last dose