# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3387411 | B | Inhibition of human recombinant AChE after 5 mins by Ellman method | Homo sapiens | 22 | single protein format | Scientific Literature | ||
2. | ALA3387412 | B | Inhibition of human plasmatic BChE after 5 mins by Ellman method | Homo sapiens | 22 | single protein format | Scientific Literature | ||
3. | ALA3387974 | B | Selectivity ratio of IC50 for human plasmatic BChE to human recombinant AChE | Homo sapiens | 22 | assay format | Scientific Literature | ||
4. | ALA3387975 | B | Inhibition of amyloid beta (1-42) self-mediated aggregation (unknown origin) at 10 uM after 24 hrs by thioflavin T fluorescence method | Homo sapiens | 22 | single protein format | Scientific Literature | ||
5. | ALA3387976 | A | Cytotoxicity against mouse Neuro2a cells assessed as reduction in cell viability after 24 hrs by MTT assay | Mus musculus | 18 | cell-based format | Scientific Literature | ||
6. | ALA3387977 | A | Cytotoxicity against rat CGN cells assessed as reduction in cell viability after 24 hrs by MTT assay | Rattus norvegicus | 18 | cell-based format | Scientific Literature | ||
7. | ALA3387978 | A | Cytotoxicity against mouse Neuro2a cells assessed as cell viability at 12.5 uM after 24 hrs by MTT assay relative to control | Mus musculus | 2 | cell-based format | Scientific Literature | ||
8. | ALA3387979 | A | Cytotoxicity against rat CGN cells assessed as cell viability at 12.5 uM after 24 hrs by MTT assay relative to control | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
9. | ALA3387980 | F | Neuroprotective effect in amyloid beta-stimulated mouse Neuro2a cells assessed as increase in cell viability at 12.5 uM after 24 hrs by MTT assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
10. | ALA3387981 | F | Antioxidant activity in tert-butyl hydroperoxide-stimulated human T67 cells assessed as reduction in intracellular ROS production at 10 uM after 24 hrs by spectrophotometry | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA3387982 | F | Antioxidant activity in tert-butyl hydroperoxide-stimulated human T67 cells assessed as reduction in intracellular ROS production at 10 uM after 24 hrs by spectrophotometry in presence of sulforaphane | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA3387983 | F | Ex vivo inhibition of AChE in ip dosed Wistar rat telencephalon measured 1 hr post dose by colorimetric method | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
13. | ALA3387984 | F | Ex vivo inhibition of AChE in Wistar rat cerebellum at 10 or 50 umol/kg, ip measured 1 hr post dose by colorimetric method | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
14. | ALA3387985 | T | Hepatotoxicity in human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
15. | ALA4391927 | B | Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured over 2 mins by UV-Vis spectrophotometric analysis based Ellman's method | Homo sapiens | 31 | single protein format | Scientific Literature | ||
16. | ALA4391928 | B | Inhibition of human recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured over 2 mins by UV-Vis spectrophotometric analysis based Ellman's method | Homo sapiens | 31 | single protein format | Scientific Literature | ||
17. | ALA4391929 | B | Selectivity index, ratio of IC50 for recombinant human BChE to IC50 for recombinant human AChE | Homo sapiens | 31 | protein format | Scientific Literature | ||
18. | ALA4391931 | B | Inhibition of HFIP pretreated amyloid beta (1-42) (unknown origin) self aggregation at 10 uM incubated for 24 hrs by thioflavin T based fluorescence assay relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
19. | ALA4391932 | A | Effective permeability of the compound in PBS buffer at pH 7.4 at 100 uM after 3 to 6 hrs by PAMPA | 23 | assay format | Scientific Literature |