| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3383964 | B | Antagonist activity at human TLR9 transfected in HEK293 cells after 6 hrs by NF-kappaB luciferase reporter assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 2. | ALA3383965 | B | Antagonist activity at human TLR7 transfected in HEK293 cells assessed as hydrolysis of pNPP after 24 hrs by SEAP reporter assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA3383966 | B | Antagonist activity at human TLR8 transfected in HEK293 cells after 6 hrs by NF-kappaB luciferase reporter assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA3383967 | F | Inhibition of CpG-induced IL-6 production in C57BL/6 mouse splenocytes after 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA3383968 | F | Inhibition of CpG-induced IL-6 production in human PBMC after 24 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3383969 | F | Inhibition of IL-6 production in iv dosed C57BL/6 mouse plasma compound administered 1 hr prior to CpG1826 treatment measured after 2 hrs by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA3383970 | F | Inhibition of IL-6 production in iv dosed C57BL/6 mouse peritoneal lavage fluid compound administered 1 hr prior to CpG1826 treatment measured after 2 hrs by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA3383971 | B | Selectivity ratio of IC50 for human TLR7 transfected in HEK293 cells to IC50 for human TLR9 transfected in HEK293 cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA3384540 | P | Aqueous solubility of the compound at pH 7.4 | 3 | small-molecule physicochemical format | Scientific Literature |
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