# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3388950 | Binding | Inhibition of human ADAMTS-4 using VQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLKG peptide substrate by AlphaScreen assay | Homo sapiens | 9 | ALA3351955 | single protein format | Scientific Literature | |
2. | ALA3388951 | Binding | Inhibition of human ADAMTS-5 using VQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLKG peptide substrate by AlphaScreen assay | Homo sapiens | 9 | ALA3351955 | single protein format | Scientific Literature | |
3. | ALA3388952 | Binding | Inhibition of human ADAMTS-5 using VQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLKG peptide substrate by AlphaScreen assay in presence of 50% rat plasma | Homo sapiens | 9 | ALA3351955 | single protein format | Scientific Literature | |
4. | ALA3388953 | Binding | Inhibition of human MMP2 using Mca-PQG1 peptide substrate assessed as substrate cleavage after 2 to 4 hrs | Homo sapiens | 9 | ALA3351955 | single protein format | Scientific Literature | |
5. | ALA3388954 | Binding | Inhibition of human MMP3 using Mca-PQG1 peptide substrate assessed as substrate cleavage after 2 to 4 hrs | Homo sapiens | 9 | ALA3351955 | single protein format | Scientific Literature | |
6. | ALA3388955 | Binding | Inhibition of human MMP13 using Mca-PQG1 peptide substrate assessed as substrate cleavage after 2 to 4 hrs | Homo sapiens | 9 | ALA3351955 | single protein format | Scientific Literature | |
7. | ALA3388956 | Binding | Inhibition of human MMP14 using Mca-PQG1 peptide substrate assessed as substrate cleavage after 2 to 4 hrs | Homo sapiens | 9 | ALA3351955 | single protein format | Scientific Literature | |
8. | ALA3388957 | Binding | Inhibition of human TACE using Mca-PQG1 peptide substrate assessed as substrate cleavage after 2 to 4 hrs | Homo sapiens | 9 | ALA3351955 | single protein format | Scientific Literature | |
9. | ALA3388958 | ADME | Plasma concentration in rat at 10 mg/kg, po after 2 hrs | Rattus norvegicus | 9 | ALA3351955 | organism-based format | Scientific Literature | |
10. | ALA3388959 | ADME | Plasma concentration in rat at 10 mg/kg, po after 8 hrs | Rattus norvegicus | 9 | ALA3351955 | organism-based format | Scientific Literature | |
11. | ALA3388960 | Functional | Reduction in ADAMTS-4/ADAMTS-5-mediated aggrecan cleavage products in po dosed Lewis rat MIA model assessed as aggrecanase-cleaved fragments treatment starting from day 3 and single dose given on day 7 followed by animal sacrificed 4 hrs later by NITEGE sandwich ELISA assay | Rattus norvegicus | 2 | ALA3351955 | organism-based format | Scientific Literature | |
12. | ALA3388961 | Functional | Reduction in meniscal tear-induced osteoarthritis total joint score in chronic BID Lewis rat surgical model | Rattus norvegicus | 2 | ALA3351955 | organism-based format | Scientific Literature | |
13. | ALA3388962 | ADME | AUC in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 3 | ALA3351955 | organism-based format | Scientific Literature | |
14. | ALA3388963 | ADME | Cmax in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 3 | ALA3351955 | organism-based format | Scientific Literature | |
15. | ALA3388964 | ADME | Tmax in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 3 | ALA3351955 | organism-based format | Scientific Literature | |
16. | ALA3388965 | ADME | Half life in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 3 | ALA3351955 | organism-based format | Scientific Literature | |
17. | ALA3388966 | ADME | Clearance in Sprague-Dawley rat | Rattus norvegicus | 3 | ALA3351955 | organism-based format | Scientific Literature | |
18. | ALA3388967 | ADME | Oral bioavailability in Sprague-Dawley rat | Rattus norvegicus | 3 | ALA3351955 | organism-based format | Scientific Literature | |
19. | ALA3388968 | ADME | Inhibition of human CYP2D6 | Homo sapiens | 3 | ALA3351955 | single protein format | Scientific Literature | |
20. | ALA3389532 | ADME | Inhibition of human CYP2C9 | Homo sapiens | 3 | ALA3351955 | single protein format | Scientific Literature |