# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3384862 | B | Competitive inhibition of N-terminal His-tagged Lyp (unknown origin) catalytic domain (1 to 294 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in pNPP hydrolysis by Lineweaver-Burk plot | Homo sapiens | 8 | ALA3351340 | assay format | Scientific Literature | |
2. | ALA3384863 | B | Reversible inhibition of N-terminal His-tagged Lyp (unknown origin) catalytic domain (1 to 294 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in pNPP hydrolysis by Lineweaver-Burk plot | Homo sapiens | 6 | ALA3351340 | assay format | Scientific Literature | |
3. | ALA3384864 | B | Inhibition of N-terminal His-tagged Lyp (unknown origin) catalytic domain (1 to 294 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in pNPP hydrolysis | Homo sapiens | 16 | ALA3351340 | assay format | Scientific Literature | |
4. | ALA3384865 | B | Inhibition of PTPN18 (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | ALA3351340 | single protein format | Scientific Literature | |
5. | ALA3384866 | B | Inhibition of STEP (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | ALA3351340 | single protein format | Scientific Literature | |
6. | ALA3384867 | B | Inhibition of MEG2 (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | ALA3351340 | single protein format | Scientific Literature | |
7. | ALA3386717 | B | Inhibition of PTP1B (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | ALA3351340 | single protein format | Scientific Literature | |
8. | ALA3386718 | B | Inhibition of VHR (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | ALA3351340 | single protein format | Scientific Literature | |
9. | ALA3386719 | B | Inhibition of SSH2 (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | ALA3351340 | single protein format | Scientific Literature | |
10. | ALA3386720 | B | Inhibition of PPM1A (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | ALA3351340 | single protein format | Scientific Literature | |
11. | ALA3386721 | B | Inhibition of PPM1G (unknown origin) assessed as reduction in pNPP hydrolysis | Homo sapiens | 4 | ALA3351340 | single protein format | Scientific Literature | |
12. | ALA3386723 | B | Inhibition of Lyp in antiCD3-antibody-stimulated human JTAg cells assessed as increase in TCR-induced LCK Y394 phosphorylation at 20 uM by immunoblotting method | Homo sapiens | 4 | ALA3351340 | cell-based format | Scientific Literature | |
13. | ALA3386724 | B | Inhibition of Lyp in antiCD3-antibody-stimulated human JTAg cells assessed as increase in TCR-induced ERK phosphorylation at 20 uM by immunoblotting method | Homo sapiens | 4 | ALA3351340 | cell-based format | Scientific Literature | |
14. | ALA3386725 | B | Inhibition of Lyp in antiCD3-antibody-stimulated human Jurkat T cells assessed as activation of TCR-mediated and IL-2 promoter driven NFAT/AP1 transcriptional activation at 20 uM incubated for 1 hr by dual luciferase reporter gene assay | Homo sapiens | 2 | ALA3351340 | cell-based format | Scientific Literature | |
15. | ALA3386726 | B | Inhibition of Lyp in antiCD3-antibody-stimulated human Jurkat T cells assessed as activation of TCR-mediated and IL-2 promoter driven NFAT/AP1 transcriptional activation incubated for 1 hr by dual luciferase reporter gene assay | Homo sapiens | 1 | ALA3351340 | cell-based format | Scientific Literature | |
16. | ALA3386727 | B | Inhibition of Lyp in antiCD3-antibody-stimulated human Jurkat T cells over-expressing Lyp assessed as activation of TCR-mediated and IL-2 promoter driven NFAT/AP1 transcriptional activation incubated for 1 hr by dual luciferase reporter gene assay | Homo sapiens | 2 | ALA3351340 | cell-based format | Scientific Literature | |
17. | ALA3387314 | B | Inhibition of VHR (unknown origin) expressed in antiCD3-antibody-stimulated human Jurkat T cells over-expressing VHR assessed as activation of TCR-mediated and IL-2 promoter driven NFAT/AP1 transcriptional activation incubated for 1 hr by dual luciferase reporter gene assay | Homo sapiens | 2 | ALA3351340 | cell-based format | Scientific Literature | |
18. | ALA3387315 | B | Inhibition of PTPN18 (unknown origin) expressed in antiCD3-antibody-stimulated human Jurkat T cells over-expressing PTPN18 assessed as activation of TCR-mediated and IL-2 promoter driven NFAT/AP1 transcriptional activation incubated for 1 hr by dual luciferase reporter gene assay | Homo sapiens | 2 | ALA3351340 | cell-based format | Scientific Literature | |
19. | ALA3387316 | B | Inhibition of STEP (unknown origin) expressed in antiCD3-antibody-stimulated human Jurkat T cells over-expressing STEP assessed as activation of TCR-mediated and IL-2 promoter driven NFAT/AP1 transcriptional activation incubated for 1 hr by dual luciferase reporter gene assay | Homo sapiens | 2 | ALA3351340 | cell-based format | Scientific Literature | |
20. | ALA3387317 | B | Inhibition of PTP1B (unknown origin) expressed in antiCD3-antibody-stimulated human Jurkat T cells over-expressing STEP assessed as activation of TCR-mediated and IL-2 promoter driven NFAT/AP1 transcriptional activation incubated for 1 hr by dual luciferase reporter gene assay | Homo sapiens | 2 | ALA3351340 | cell-based format | Scientific Literature |