# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA650012 | Binding | In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated guinea pig atria | Cavia porcellus | 53 | ALA1123279 | single protein format | Scientific Literature | |
2. | ALA651636 | Binding | In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha contracted guinea pig trachea | Cavia porcellus | 50 | ALA1123279 | single protein format | Scientific Literature | |
3. | ALA659806 | Functional | In vivo beta adrenergic blocking potency was determined by inhibition of tachycardia produced by isoproterenol (0.2 mg/kg iv) in cat preparation | Felis catus | 40 | ALA1122166 | organism-based format | Scientific Literature | |
4. | ALA656449 | Functional | In vivo beta adrenergic blocking potency was determined by inhibition of depressor response produced by isoproterenol (0.2 mg/kg iv) in cat preparation | Felis catus | 40 | ALA1122166 | organism-based format | Scientific Literature | |
5. | ALA848336 | Binding | The cardioselectivity ratio was obtained by taking the antilog (pA2 beta1-pA2 beta2) | Cavia porcellus | 51 | ALA1123279 | protein format | Scientific Literature | |
6. | ALA780598 | Functional | Effective dose was evaluated following intravenous administration in reserpinized normotensive anesthetized rats | Rattus norvegicus | 1 | ALA1123279 | organism-based format | Scientific Literature | |
7. | ALA2351570 | Binding | Selectivity ratio of Kd for human beta1 adrenoceptor expressed in CHOK1 cells by c-AMP accumulation assay to Kd for human beta2 adrenoceptor expressed in CHOK1 cells by c-AMP accumulation assay | Homo sapiens | 10 | ALA2346523 | cell-based format | Scientific Literature | |
8. | ALA2351574 | Functional | Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of 3H]cAMP accumulation after 5 hrs relative to isoprenaline | Homo sapiens | 3 | ALA2346523 | cell-based format | Scientific Literature | |
9. | ALA2351576 | Functional | Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation at 10 uM after 5 hrs relative to isoprenaline | Homo sapiens | 8 | ALA2346523 | cell-based format | Scientific Literature | |
10. | ALA2351578 | Functional | Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs | Homo sapiens | 11 | ALA2346523 | cell-based format | Scientific Literature | |
11. | ALA2351580 | Functional | Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs | Homo sapiens | 11 | ALA2346523 | cell-based format | Scientific Literature | |
12. | ALA2351581 | Functional | Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation measured after 5 hrs relative to isoprenaline | Homo sapiens | 11 | ALA2346523 | cell-based format | Scientific Literature | |
13. | ALA2351582 | Functional | Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs | Homo sapiens | 12 | ALA2346523 | cell-based format | Scientific Literature | |
14. | ALA2351583 | Functional | Antagonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs | Homo sapiens | 10 | ALA2346523 | cell-based format | Scientific Literature | |
15. | ALA2351584 | Functional | Antagonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs | Homo sapiens | 10 | ALA2346523 | cell-based format | Scientific Literature | |
16. | ALA2351585 | Functional | Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated for 15 mins prior to cimaterol induction measured after 5 hrs | Homo sapiens | 10 | ALA2346523 | cell-based format | Scientific Literature | |
17. | ALA2351859 | Binding | Selectivity ratio of Kd for human beta1 adrenoceptor expressed in CHOK1 cells by radioligand displacement assay to Kd for human beta2 adrenoceptor expressed in CHOK1 cells by radioligand displacement assay | Homo sapiens | 27 | ALA2346523 | cell-based format | Scientific Literature | |
18. | ALA2351860 | Binding | Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysis | Homo sapiens | 30 | ALA2346523 | cell-based format | Scientific Literature | |
19. | ALA2351861 | Binding | Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysis | Homo sapiens | 30 | ALA2346523 | cell-based format | Scientific Literature |