| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3395210 | A | Cytotoxic activity against human HepG2 cells assessed as cell viability at 10 uM after 48 hrs by LDH release assay (Rvb = 100%) | Homo sapiens | 4 | ALA3393039 | cell-based format | Scientific Literature | |
| 2. | ALA3395211 | A | Cytotoxic activity against human HepG2 cells assessed as cell viability at 30 uM after 48 hrs by LDH release assay (Rvb = 100%) | Homo sapiens | 4 | ALA3393039 | cell-based format | Scientific Literature | |
| 3. | ALA3395212 | P | Aqueous solubility of the compound | 4 | ALA3393039 | small-molecule physicochemical format | Scientific Literature | ||
| 4. | ALA3395310 | A | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as parent compound remaining at 10 uM measured after 15 mins in presence of NADPH regenerating system by HPLC method (Rvb = 97.6 +/- 0.8%) | Rattus norvegicus | 1 | ALA3393039 | assay format | Scientific Literature | |
| 5. | ALA3395311 | A | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as parent compound remaining at 10 uM measured after 30 mins in presence of NADPH regenerating system by HPLC method (Rvb = 97.6 +/- 0.8%) | Rattus norvegicus | 1 | ALA3393039 | assay format | Scientific Literature | |
| 6. | ALA3395312 | A | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as parent compound remaining at 10 uM measured after 60 mins in presence of NADPH regenerating system by HPLC method (Rvb = 97.6 +/- 0.8%) | Rattus norvegicus | 1 | ALA3393039 | assay format | Scientific Literature | |
| 7. | ALA3395313 | B | Selectivity index, ratio of EC50 for Gal4-tagged PPARgamma ligand binding domain (unknown origin) to EC50 for Gal4-tagged PPARdelta ligand binding domain (unknown origin) | Homo sapiens | 1 | ALA3393039 | assay format | Scientific Literature | |
| 8. | ALA3395861 | B | Transactivation of Gal4-tagged PPARalpha ligand binding domain (unknown origin) expressed in COS7 cells measured after overnight incubation by luciferase reporter gene assay | Homo sapiens | 22 | ALA3393039 | cell-based format | Scientific Literature | |
| 9. | ALA3395864 | B | Transactivation of Gal4-tagged PPARalpha ligand binding domain (unknown origin) expressed in COS7 cells measured after overnight incubation by luciferase reporter gene assay relative to GW7647 | Homo sapiens | 22 | ALA3393039 | cell-based format | Scientific Literature | |
| 10. | ALA3395994 | B | Transactivation of Gal4-tagged PPARgamma ligand binding domain (unknown origin) expressed in COS7 cells measured after overnight incubation by luciferase reporter gene assay | Homo sapiens | 35 | ALA3393039 | cell-based format | Scientific Literature | |
| 11. | ALA3395995 | B | Transactivation of Gal4-tagged PPARgamma ligand binding domain (unknown origin) expressed in COS7 cells measured after overnight incubation by luciferase reporter gene assay relative to piaglitazone | Homo sapiens | 35 | ALA3393039 | cell-based format | Scientific Literature | |
| 12. | ALA3395999 | B | Transactivation of Gal4-tagged PPARdelta ligand binding domain (unknown origin) expressed in COS7 cells measured after overnight incubation by luciferase reporter gene assay | Homo sapiens | 14 | ALA3393039 | cell-based format | Scientific Literature | |
| 13. | ALA3396000 | B | Transactivation of Gal4-tagged PPARdelta ligand binding domain (unknown origin) expressed in COS7 cells measured after overnight incubation by luciferase reporter gene assay relative to L165,041 | Homo sapiens | 14 | ALA3393039 | cell-based format | Scientific Literature | |
| 14. | ALA3396001 | B | Transactivation of human FXR expressed in human HeLa cells incubated for 24 hrs by luciferase reporter gene assay | Homo sapiens | 36 | ALA3393039 | cell-based format | Scientific Literature | |
| 15. | ALA3396002 | B | Transactivation of human FXR expressed in human HeLa cells incubated for 24 hrs by luciferase reporter gene assay relative to GW4064 | Homo sapiens | 36 | ALA3393039 | cell-based format | Scientific Literature | |
| 16. | ALA3396005 | B | Selectivity index, ratio of EC50 for Gal4-tagged PPARalpha ligand binding domain (unknown origin) to EC50 for Gal4-tagged PPARdelta ligand binding domain (unknown origin) | Homo sapiens | 1 | ALA3393039 | assay format | Scientific Literature | |
| 17. | ALA3396006 | A | Antiproliferative activity against human HepG2 cells assessed as cell viability at 5 uM after 48 hrs by WST1 assay (Rvb = 100%) | Homo sapiens | 4 | ALA3393039 | cell-based format | Scientific Literature | |
| 18. | ALA3396007 | A | Antiproliferative activity against human HepG2 cells assessed as cell viability at 10 uM after 48 hrs by WST1 assay (Rvb = 100%) | Homo sapiens | 4 | ALA3393039 | cell-based format | Scientific Literature | |
| 19. | ALA3396008 | A | Antiproliferative activity against human HepG2 cells assessed as cell viability at 50 uM after 48 hrs by WST1 assay (Rvb = 100%) | Homo sapiens | 4 | ALA3393039 | cell-based format | Scientific Literature | |
| 20. | ALA3396009 | A | Cytotoxic activity against human HepG2 cells assessed as cell viability at 5 uM after 48 hrs by LDH release assay (Rvb = 100%) | Homo sapiens | 4 | ALA3393039 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!