| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3396112 | P | Lipophilicity, log D of the compound at pH 7.4 by shake flask method | 9 | small-molecule physicochemical format | Scientific Literature | |||
| 2. | ALA3396113 | B | Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 3. | ALA3396114 | B | Inverse agonist activity at human GHS-R1a expressed in tetracycline inducible HEK293 cells incubated for 24 hrs prior to europium-labeled GTP addition measured after 90 mins by DELFIA assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 4. | ALA3396115 | B | Inverse agonist activity at human GHS-R1a expressed in tetracycline inducible HEK293 cells incubated for 24 hrs prior to europium-labeled GTP addition measured after 90 mins by DELFIA assay relative to control | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 5. | ALA3396116 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 6. | ALA3396117 | A | Ratio of permeability from basolateral to apical side to permeability from apical to basolateral side in MDCK cells expressing human MDR-1 gene | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 7. | ALA3396118 | A | Passive permeability in low efflux MDCK2 cells | Canis lupus familiaris | 12 | cell-based format | Scientific Literature | ||
| 8. | ALA3396119 | P | Chemical stability in pH 7.4 PBS buffer at 37 degC assessed as disappearance of parent compound peak and appearance of new compound peak by UPLC-MS method | 12 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA3396343 | A | Intrinsic clearance in rat liver microsomes | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 10. | ALA3396344 | A | Intrinsic clearance in dog liver microsomes | Canis lupus familiaris | 2 | assay format | Scientific Literature | ||
| 11. | ALA3396345 | A | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA3396346 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA3396347 | A | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA3396348 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA3396349 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 16. | ALA3396350 | P | Kinetic solubility in 2% sodium phosphate buffer at pH 6.5 after 24 hrs | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 17. | ALA3396351 | B | Inhibition of human ERG by patch clamp assay | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 18. | ALA3396352 | B | Inhibition of 5HT2B receptor (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 19. | ALA3396353 | T | Toxicity in human THLE cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA3396354 | T | Genotoxicity in Salmonella typhimurium assessed as induction of bacterial reverse mutation up to 600 uM by Amest test | Salmonella enterica subsp. enterica serovar Typhimurium | 1 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!