# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3396589 | F | Antifungal activity against Histoplasma capsulatum G217B ATCC 26032 assessed as inhibition of visible growth after 5 days | Histoplasma capsulatum G217B | 67 | ALA3393037 | assay format | Scientific Literature | |
2. | ALA3396590 | F | Antifungal activity against Cryptococcus neoformans MATalpha serotype A strain H99 assessed as inhibition of visible growth after 5 days | Cryptococcus neoformans | 65 | ALA3393037 | organism-based format | Scientific Literature | |
3. | ALA3396591 | A | Cytotoxicity against human HepG2 cells after 72 hrs by crystal violet staining method | Homo sapiens | 55 | ALA3393037 | cell-based format | Scientific Literature | |
4. | ALA3396592 | U | Selectivity index, ratio of MIC50 for Histoplasma capsulatum strain G217B ATCC 26032 to MIC50 for human HepG2 cells | 53 | ALA3393037 | cell-based format | Scientific Literature | ||
5. | ALA3396593 | A | Cytotoxicity against mouse P388D1 HepG2 cells after 48 hrs by crystal violet staining method | Mus musculus | 1 | ALA3393037 | cell-based format | Scientific Literature | |
6. | ALA4222852 | F | Antifungal activity against Histoplasma capsulatum G217B ATCC 26032 at pH 7 measured over 5 days | Histoplasma capsulatum | 35 | ALA4219175 | organism-based format | Scientific Literature | |
7. | ALA4222853 | F | Antifungal activity against wild type fluconazole-sensitive Cryptococcus neoformans serotype A H99 at pH 7 measured over 4 days | Cryptococcus neoformans | 36 | ALA4219175 | organism-based format | Scientific Literature | |
8. | ALA4222854 | A | Cytotoxicity against mouse P388D1 cells assessed as reduction in cell viability after 72 hrs by resazurin-based fluorescence assay | Mus musculus | 35 | ALA4219175 | cell-based format | Scientific Literature | |
9. | ALA4222855 | T | Therapeutic index, ratio of IC50 for mouse P388D1 cells to IC50 for Histoplasma capsulatum G217B ATCC 26032 | 35 | ALA4219175 | assay format | Scientific Literature | ||
10. | ALA4222856 | T | Therapeutic index, ratio of IC50 for mouse P388D1 cells to IC50 for wild type Cryptococcus neoformans serotype A H99 | 35 | ALA4219175 | assay format | Scientific Literature | ||
11. | ALA4222857 | F | Antifungal activity against wild-type fluconazole-sensitive Cryptococcus neoformans serotype D B3501 measured over 4 days | Cryptococcus neoformans | 7 | ALA4219175 | organism-based format | Scientific Literature | |
12. | ALA4222858 | F | Antifungal activity against fluconazole-resistant Cryptococcus neoformans serotype A TES9 harboring erg11 mutant measured over 4 days | Cryptococcus neoformans | 7 | ALA4219175 | organism-based format | Scientific Literature | |
13. | ALA4222859 | F | Antifungal activity against fluconazole-resistant Cryptococcus neoformans serotype A MRL862 harboring erg11 mutant measured over 4 days | Cryptococcus neoformans | 7 | ALA4219175 | organism-based format | Scientific Literature | |
14. | ALA4222860 | F | Antifungal activity against RFP expressing Histoplasma capsulatum infected in LacZ-expressing mouse P388D1 cells incubated for 6 days measured daily by fluorescence assay | Histoplasma capsulatum | 4 | ALA4219175 | organism-based format | Scientific Literature | |
15. | ALA4222861 | P | Aqueous solubility of the compound at pH 5 | 9 | ALA4219175 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA4222862 | P | Aqueous solubility of the compound at pH 7 | 9 | ALA4219175 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA4222863 | P | Ratio of aqueous solubility at pH 5 to aqueous solubility at pH 7 | 9 | ALA4219175 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA4222864 | F | Antifungal activity against Histoplasma capsulatum G217B ATCC 26032 at pH 5 measured over 5 days | Histoplasma capsulatum | 9 | ALA4219175 | organism-based format | Scientific Literature | |
19. | ALA4222865 | F | Antifungal activity against wild type fluconazole-sensitive Cryptococcus neoformans serotype A H99 at pH 5 measured over 4 days | Cryptococcus neoformans | 9 | ALA4219175 | organism-based format | Scientific Literature | |
20. | ALA4222866 | F | Fungistatic activity against Histoplasma capsulatum OSU76 after 2 to 24 hrs by colony forming assay | Histoplasma capsulatum | 1 | ALA4219175 | organism-based format | Scientific Literature |