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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA3396816 Binding Inhibition of SCD1 in ICR mouse liver microsome using [9,10 3H]- stearoyl-Coenzyme A substrate assessed as decreased production of tritiated water after 20 hrs by scintillation counting analysis Mus musculus 29 ALA3393027 microsome format Scientific Literature 2. ALA3396817 Binding Inhibition of SCD1 in human HepG2 cells using [14C]-stearate substrate assessed as decreased production of [14C]-oleic acid after 24 hrs Homo sapiens 29 ALA3393027 cell-based format Scientific Literature 3. ALA3396818 ADME Metabolic stability in rat liver microsome assessed as compound remaining after 30 mins by LC/MS/MS analysis Rattus norvegicus 29 ALA3393027 microsome format Scientific Literature 4. ALA3396819 Functional Antiobesity activity in Lewis rat DI model assessed as reduction in plasma C16:1/C16:0 TG desaturation index at 5 mg/kg, po after 4 hrs Rattus norvegicus 6 ALA3393027 organism-based format Scientific Literature 5. ALA3396820 ADME Permeability from apical to basolateral side in human Caco2 cells Homo sapiens 29 ALA3393027 cell-based format Scientific Literature 6. ALA3396821 ADME Clearance in Lewis rat at 1 mg/kg, iv Rattus norvegicus 1 ALA3393027 organism-based format Scientific Literature 7. ALA3396822 ADME Half life in Lewis rat at 1 mg/kg, iv Rattus norvegicus 1 ALA3393027 organism-based format Scientific Literature 8. ALA3396823 ADME Cmax in Lewis rat at 1 mg/kg, iv Rattus norvegicus 1 ALA3393027 organism-based format Scientific Literature 9. ALA3396824 ADME Volume of distribution at steady state in Lewis rat at 1 mg/kg, iv Rattus norvegicus 1 ALA3393027 organism-based format Scientific Literature 10. ALA3396825 ADME Terminal half life in Lewis rat at 5 mg/kg, po Rattus norvegicus 1 ALA3393027 organism-based format Scientific Literature 11. ALA3396826 ADME AUC (0 to 24 hrs) in Lewis rat at 1 mg/kg, iv Rattus norvegicus 1 ALA3393027 organism-based format Scientific Literature 12. ALA3396827 ADME Cmax in Lewis rat at 5 mg/kg, po Rattus norvegicus 1 ALA3393027 organism-based format Scientific Literature 13. ALA3396828 ADME Tmax in Lewis rat at 5 mg/kg, po Rattus norvegicus 1 ALA3393027 organism-based format Scientific Literature 14. ALA3396829 ADME AUC (0 to 24 hrs) at steady state in Lewis rat at 5 mg/kg, po Rattus norvegicus 1 ALA3393027 organism-based format Scientific Literature 15. ALA3396830 ADME Oral bioavailability in Lewis rat at 5 mg/kg Rattus norvegicus 1 ALA3393027 organism-based format Scientific Literature 16. ALA3396832 Toxicity Toxicity in female Sprague-Dawley rat assessed as induction of red eye at 100 mg/kg, po once daily for 10 consecutive days Rattus norvegicus 8 ALA3393027 organism-based format Scientific Literature 17. ALA3396833 ADME AUC (0 to 24 hrs) in female Sprague-Dawley rat at 100 mg/kg, po once daily for 10 consecutive days measured on day 11 Rattus norvegicus 1 ALA3393027 organism-based format Scientific Literature 18. ALA3396834 Functional Antiobesity activity in po dosed Lewis rat DI model assessed as reduction in plasma C16:1/C16:0 TG desaturation index after 4 hrs Rattus norvegicus 1 ALA3393027 organism-based format Scientific Literature 19. ALA3396835 ADME Permeability from basolateral to apical side side in human Caco2 cells Homo sapiens 29 ALA3393027 cell-based format Scientific Literature 20. ALA3396836 Binding Inhibition of delta5 desaturase in Sprague-Dawley rat liver microsome at 10 uM by thin layer chromatography method Rattus norvegicus 23 ALA3393027 microsome format Scientific Literature