# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3399761 | Binding | Inhibition of human neutrophil elastase measured for 30 mins by spectrophotometry | Homo sapiens | 24 | ALA3396960 | single protein format | Scientific Literature | |
2. | ALA3399762 | Binding | Inhibition of Pr3 (unknown origin) using t-butyloxycarbonyl-Ala-Ala-Nva-thiobenzyl ester as substrate measured for 180 mins by spectrophotometry | Homo sapiens | 24 | ALA3396960 | single protein format | Scientific Literature | |
3. | ALA3399763 | Binding | Inhibition of human cathepsin G using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrate measured for 180 mins by spectrophotometry | Homo sapiens | 24 | ALA3396960 | single protein format | Scientific Literature | |
4. | ALA3399764 | Functional | Inhibition of superoxide generation in fMLF/CB-induced human neutrophils preincubated for 5 mins before fMLF/CB treatment by spectrophotometry | Homo sapiens | 24 | ALA3396960 | cell-based format | Scientific Literature | |
5. | ALA3399765 | Functional | Inhibition of elastase release in fMLF/CB-induced human neutrophils preincubated for 5 mins before fMLF/CB treatment using methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide as substrate by spectrophotometry | Homo sapiens | 24 | ALA3396960 | cell-based format | Scientific Literature | |
6. | ALA3399766 | Binding | Inhibition of bovine pancreatic trypsin using Nalpha-benzoyl-L-arginine-7-amido-4-methylcoumarin | Bos taurus | 2 | ALA3396960 | assay format | Scientific Literature | |
7. | ALA3399767 | Binding | Inhibition of bovine pancreas chymotrypsin using N-succinyl-Ala-Ala-Pro-Phe-7-amido-4-methylcoumarin by spectrophotometry | Bos taurus | 2 | ALA3396960 | assay format | Scientific Literature | |
8. | ALA3399768 | Binding | Inhibition of bovine plasma thrombin using Benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin hydrochloride by spectrophotometry | Bos taurus | 2 | ALA3396960 | single protein format | Scientific Literature | |
9. | ALA3399769 | Binding | Selectivity index, ratio of IC50 for Pr3 (unknown origin) to IC50 for human neutrophil elastase | Homo sapiens | 2 | ALA3396960 | assay format | Scientific Literature | |
10. | ALA3399770 | Binding | Selectivity index, ratio of IC50 for human cathepsin G to IC50 for human neutrophil elastase | Homo sapiens | 2 | ALA3396960 | assay format | Scientific Literature | |
11. | ALA3399771 | Binding | Selectivity index, ratio of IC50 for bovine pancreas trypsin to IC50 for human neutrophil elastase | 2 | ALA3396960 | assay format | Scientific Literature | ||
12. | ALA3399772 | Binding | Selectivity index, ratio of IC50 for bovine pancreas chymotrypsin to IC50 for human neutrophil elastase | 2 | ALA3396960 | assay format | Scientific Literature | ||
13. | ALA3399773 | Binding | Selectivity index, ratio of IC50 for bovine plasma thrombin to IC50 for human neutrophil elastase | 2 | ALA3396960 | assay format | Scientific Literature | ||
14. | ALA3399809 | Binding | Inhibition of recombinant mouse neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pnitroanilide as substrate preincubated for 15 mins before substrate addition measured after 90 mins by spectrophotometry | Mus musculus | 2 | ALA3396960 | single protein format | Scientific Literature | |
15. | ALA3399810 | Binding | Inhibition of porcine pancreatic elastase using methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide as substrate preincubated for 15 mins before substrate addition measured after 60 mins by spectrophotometry | Sus scrofa | 2 | ALA3396960 | protein format | Scientific Literature | |
16. | ALA3399813 | Functional | Antiinflammatory activity in C57BL/6 mouse assessed as inhibition of human neutrophil elastase-induced edema compound treated ip 1 hr prior challenge measured up to 240 mins post dose | Mus musculus | 1 | ALA3396960 | organism-based format | Scientific Literature | |
17. | ALA3399814 | Functional | Antiinflammatory activity in C57BL/6 mouse assessed as inhibition of human neutrophil elastase-induced edema compound treated 1 hr prior challenge at 50 to 100 mg/kg, ip | Mus musculus | 1 | ALA3396960 | organism-based format | Scientific Literature | |
18. | ALA3399815 | Functional | Antiinflammatory activity in C57BL/6 mouse assessed as inhibition of LPS-induced edema compound treated 1 hr prior challenge at 100 mg/kg, ip measured up to 240 mins | Mus musculus | 2 | ALA3396960 | organism-based format | Scientific Literature | |
19. | ALA3399816 | Functional | Protection from LPS-induced acute liver injury in C57BL/6 mouse assessed as inhibition of MPO activity in lung tissue treated 1 hr prior challenge at 100 mg/kg, ip | Mus musculus | 2 | ALA3396960 | organism-based format | Scientific Literature | |
20. | ALA3399817 | Functional | Protection from LPS-induced acute liver injury in C57BL/6 mouse assessed as inhibition of leukocyte infiltration in lung treated 1 hr prior challenge at 100 mg/kg, ip | Mus musculus | 2 | ALA3396960 | organism-based format | Scientific Literature |