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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA3399384 B Activation of human TLR7 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assay Homo sapiens 7 cell-based format Scientific Literature 2. ALA3399385 B Activation of human TLR8 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assay Homo sapiens 7 cell-based format Scientific Literature 3. ALA3399386 T Toxicity against human TLR8 expressing HEK293 cells after 24 hrs by live/dead fixable aqua staining method Homo sapiens 6 cell-based format Scientific Literature 4. ALA3399387 F Induction of TNFalpha production in primary human PBMC after 24 hrs by ELISA method Homo sapiens 7 cell-based format Scientific Literature 5. ALA3399388 F Induction of IL6 expression in human HLA-DR(+), CD11c(+) and CD123(-) expressing mDC after 24 hrs by intracellular cytokine staining method Homo sapiens 6 cell-based format Scientific Literature 6. ALA3399389 F Induction of IFNgamma production in primary human PBMC after 24 hrs by ELISA method Homo sapiens 7 cell-based format Scientific Literature 7. ALA3399390 F Induction of IFNalpha production in primary human PBMC at 0.001 to 10 uM after 24 hrs by ELISA method Homo sapiens 7 cell-based format Scientific Literature 8. ALA3399391 F Induction of TNFalpha production in primary human PBMC at 0.001 to 10 uM after 24 hrs by ELISA method Homo sapiens 5 cell-based format Scientific Literature 9. ALA3399392 F Reduction in IFNalpha production in primary human PBMC at >10 uM after 24 hrs by ELISA method Homo sapiens 6 cell-based format Scientific Literature 10. ALA3399393 F Induction of apoptosis in human HLA-DR(+), CD11c(-) and CD123(+) expressing pDC at 1 nM after 24 hrs by Annexin-V staining method Homo sapiens 1 assay format Scientific Literature 11. ALA3399394 F Induction of apoptosis in human HLA-DR(+), CD11c(+) and CD123(-) expressing mDC at 1 nM after 24 hrs by Annexin-V staining method Homo sapiens 1 assay format Scientific Literature 12. ALA3399444 F Induction of TNFalpha production in human HLA-DR(+), CD11c(+) and CD123(-) expressing mDC after 24 hrs by ELISA method Homo sapiens 2 assay format Scientific Literature 13. ALA3399445 F Induction of TNFalpha production in human HLA-DR(+), CD11c(+) and CD123(-) expressing mDC after 24 hrs by intracellular cytokine staining method Homo sapiens 2 cell-based format Scientific Literature 14. ALA3399446 F Induction of INFalpha production in human HLA-DR(+), CD11c(+) and CD123(-) expressing mDC after 24 hrs by ELISA method Homo sapiens 2 assay format Scientific Literature 15. ALA3399447 F Induction of INFalpha production in human HLA-DR(+), CD11c(+) and CD123(-) expressing mDC after 24 hrs by intracellular cytokine staining method Homo sapiens 2 cell-based format Scientific Literature 16. ALA3399448 F Induction of TNFalpha production in human HLA-DR(+), CD11c(-) and CD123(+) expressing pDC after 24 hrs by ELISA method Homo sapiens 2 assay format Scientific Literature 17. ALA3399449 F Induction of TNFalpha production in human HLA-DR(+), CD11c(-) and CD123(+) expressing pDC after 24 hrs by intracellular cytokine staining method Homo sapiens 2 cell-based format Scientific Literature 18. ALA3399450 F Induction of INFalpha production in human HLA-DR(+), CD11c(-) and CD123(+) expressing pDC after 24 hrs by ELISA method Homo sapiens 2 assay format Scientific Literature 19. ALA3399451 F Induction of INFalpha production in human HLA-DR(+), CD11c(-) and CD123(+) expressing pDC after 24 hrs by intracellular cytokine staining method Homo sapiens 2 cell-based format Scientific Literature 20. ALA4627760 B Agonist activity at TLR8 in human PBMC assessed as induction of myeloid dendritic cell maturation by measuring increase in CD80 level at 0.1 uM after 6 hrs by flow cytometry relative to control Homo sapiens 4 cell-based format Scientific Literature