| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3405144 | A | Drug metabolism in Sprague-Dawley rat liver S9 fraction assessed as compound remaining at 1 uM after 30 mins by HPLC/MS/MS analysis relative to control | Rattus norvegicus | 12 | subcellular format | Scientific Literature | ||
| 2. | ALA3405145 | A | Drug metabolism in rat serum assessed as compound remaining at 1 uM after 30 mins by HPLC/MS/MS analysis relative to control | Rattus norvegicus | 12 | cell-free format | Scientific Literature | ||
| 3. | ALA3405146 | A | Drug metabolism in human liver S9 fraction assessed as compound remaining at 1 uM after 30 mins by HPLC/MS/MS analysis relative to control | Homo sapiens | 12 | subcellular format | Scientific Literature | ||
| 4. | ALA3405147 | A | Drug metabolism in human serum assessed as compound remaining at 1 uM after 30 mins by HPLC/MS/MS analysis relative to control | Homo sapiens | 12 | cell-free format | Scientific Literature | ||
| 5. | ALA3405148 | A | Drug metabolism in Sprague-Dawley rat liver S9 fraction assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid formation at 1 uM after 30 mins by HPLC/MS/MS analysis relative to control | Rattus norvegicus | 9 | subcellular format | Scientific Literature | ||
| 6. | ALA3405151 | A | Drug metabolism in rat serum assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid formation at 1 uM after 30 mins by HPLC/MS/MS analysis relative to control | Rattus norvegicus | 9 | cell-free format | Scientific Literature | ||
| 7. | ALA3405154 | A | Drug metabolism in human liver S9 fraction assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid formation at 1 uM after 30 mins by HPLC/MS/MS analysis relative to control | Homo sapiens | 9 | subcellular format | Scientific Literature | ||
| 8. | ALA3405157 | A | Drug metabolism in human serum assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid formation at 1 uM after 30 mins by HPLC/MS/MS analysis relative to control | Homo sapiens | 9 | cell-free format | Scientific Literature | ||
| 9. | ALA3405160 | A | Permeability of the compound at pH 5 by PAMPA | 14 | assay format | Scientific Literature | |||
| 10. | ALA3405161 | A | Permeability of the compound at pH 7.4 by PAMPA | 14 | assay format | Scientific Literature | |||
| 11. | ALA3405177 | B | Inhibition of human DPP4 | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 12. | ALA3405178 | A | Cmax in rat assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid level at 20 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA3405181 | A | Tmax in rat assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid level at 20 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA3405355 | A | AUC in rat assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid level at 20 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA3405359 | A | Oral bioavailability in rat assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid level at 20 mg/kg | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3405363 | P | Solubility of the compound at pH 7.4 | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 17. | ALA3405364 | P | Solubility of the compound at pH 5.5 | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 18. | ALA3406651 | P | Solubility of the compound at pH 2.5 | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 19. | ALA3406652 | A | Plasma concentration in rat at 20 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA3406653 | F | In vivo inhibition of DPP4 in Sprague-Dawley rat at 3 mg/kg, po after 1 hr | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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