Drug metabolism in Sprague-Dawley rat liver S9 fraction assessed as compound remaining at 1 uM after 30 mins by HPLC/MS/MS analysis relative to control
Drug metabolism in Sprague-Dawley rat liver S9 fraction assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid formation at 1 uM after 30 mins by HPLC/MS/MS analysis relative to control
Drug metabolism in rat serum assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid formation at 1 uM after 30 mins by HPLC/MS/MS analysis relative to control
Drug metabolism in human liver S9 fraction assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid formation at 1 uM after 30 mins by HPLC/MS/MS analysis relative to control
Drug metabolism in human serum assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid formation at 1 uM after 30 mins by HPLC/MS/MS analysis relative to control
Cmax in rat assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chloro-5-fluorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid level at 10 mg/kg, po
Tmax in rat assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chloro-5-fluorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid level at 10 mg/kg, po
AUC in rat assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chloro-5-fluorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid level at 10 mg/kg, po
Oral bioavailability in rat assessed as 2-(3-aminopiperidin-1-yl)-3-(2-chloro-5-fluorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinoline-8-carboxylic acid level at 10 mg/kg