# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3405600 | F | Antagonist activity at human S1P2 receptor overexpressed in CHO cells assessed as increase in intracellular calcium ion concentration incubated 3 mins prior to S1P challenge by fluorescence assay | Homo sapiens | 24 | ALA3400022 | cell-based format | Scientific Literature | |
2. | ALA3405601 | F | Antagonist activity at human LPA1 receptor overexpressed in CHO cells assessed as increase in intracellular calcium ion concentration after 3 mins by fluorescence assay | Homo sapiens | 12 | ALA3400022 | cell-based format | Scientific Literature | |
3. | ALA3405602 | F | Antagonist activity at human S1P3 receptor overexpressed in CHO cells assessed as increase in intracellular calcium ion concentration after 3 mins by fluorescence assay | Homo sapiens | 12 | ALA3400022 | cell-based format | Scientific Literature | |
4. | ALA3405603 | F | Antagonist activity at human LPA2 receptor overexpressed in CHO cells assessed as increase in intracellular calcium ion concentration after 3 mins by fluorescence assay | Homo sapiens | 12 | ALA3400022 | cell-based format | Scientific Literature | |
5. | ALA3405604 | B | Displacement of [33P]-S1P from human S1P2 receptor expressed in CHOK1 cells after 60 mins by scintillation counting analysis | Homo sapiens | 16 | ALA3400022 | cell-based format | Scientific Literature | |
6. | ALA3619044 | F | Antagonist activity at human S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assay | Homo sapiens | 14 | ALA3616460 | cell-based format | Scientific Literature | |
7. | ALA3619045 | B | Displacement of [33P]S1P from human S1P2 expressed in CHO-K1 cells by scintillation counter | Homo sapiens | 2 | ALA3616460 | cell-based format | Scientific Literature | |
8. | ALA3619046 | F | Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assay | Rattus norvegicus | 14 | ALA3616460 | cell-based format | Scientific Literature | |
9. | ALA3619047 | A | Metabolic stability in human liver microsome assessed as compound remaining after 15 mins by LC-MS/MS analysis | Homo sapiens | 13 | ALA3616460 | microsome format | Scientific Literature | |
10. | ALA3619048 | A | Metabolic stability in rat liver microsome assessed as compound remaining after 15 mins by LC-MS/MS analysis | Rattus norvegicus | 14 | ALA3616460 | microsome format | Scientific Literature | |
11. | ALA3619049 | B | Selectivity index, ratio of IC50 for human S1P2 to IC50 for rat S1P2 | 13 | ALA3616460 | assay format | Scientific Literature | ||
12. | ALA3619050 | A | Cytotoxicity against human hepatocytes assessed as ATP level by luminescent assay | Homo sapiens | 13 | ALA3616460 | cell-based format | Scientific Literature | |
13. | ALA5099154 | B | Binding affinity to S1PR2 (unknown origin) assessed as dissociation constant by surface plasmon resonance analysis | Homo sapiens | 41 | ALA5096216 | single protein format | Scientific Literature |