Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 infected in human red blood cells assessed as reduction in parasite viability after 48 hrs by [3H]-hypoxanthine incorporation assay
Antiplasmodial activity against GFP-transfected Plasmodium berghei ANKA infected in NMRI mouse assessed as reduction in parasitemia at 50 mg/kg, ip administered 4, 24, 48 and 72 hrs post infection by FACS analysis
Antiplasmodial activity against GFP-transfected Plasmodium berghei ANKA infected in NMRI mouse assessed as reduction in parasitemia at 10 mg/kg, ip administered 4, 24, 48 and 72 hrs post infection by FACS analysis
Antiplasmodial activity against GFP-transfected Plasmodium berghei ANKA infected in NMRI mouse assessed as reduction in parasitemia at 20 mg/kg, ip administered 4, 24, 48 and 72 hrs post infection by FACS analysis
Antiplasmodial activity against GFP-transfected Plasmodium berghei ANKA infected in NMRI mouse assessed as reduction in parasitemia at 100 mg/kg, po administered 4, 24, 48 and 72 hrs post infection by FACS analysis
Antiplasmodial activity against GFP-transfected Plasmodium berghei ANKA infected in NMRI mouse assessed as reduction in parasitemia at 100 mg/kg, po administered 24 hrs post infection by FACS analysis
Antiplasmodial activity against GFP-transfected Plasmodium berghei ANKA infected in NMRI mouse assessed as reduction in parasitemia at 200 mg/kg, po administered 24 hrs post infection by FACS analysis
Antiplasmodial activity against GFP-transfected Plasmodium berghei ANKA infected in NMRI mouse assessed as mean survival day at 50 mg/kg, ip administered 4, 24, 48 and 72 hrs post infection (Rvb = 4 to 6 days)
Antiplasmodial activity against GFP-transfected Plasmodium berghei ANKA infected in NMRI mouse assessed as mean survival day at 10 mg/kg, ip administered 4, 24, 48 and 72 hrs post infection (Rvb = 4 days)
Antiplasmodial activity against GFP-transfected Plasmodium berghei ANKA infected in NMRI mouse assessed as mean survival day at 20 mg/kg, ip administered 4, 24, 48 and 72 hrs post infection (Rvb = 4 days)
Antiplasmodial activity against GFP-transfected Plasmodium berghei ANKA infected in NMRI mouse assessed as mean survival day at 100 mg/kg, po administered 4, 24, 48 and 72 hrs post infection (Rvb = 4 days)
Antiplasmodial activity against GFP-transfected Plasmodium berghei ANKA infected in NMRI mouse assessed as mean survival day at 100 mg/kg, po administered 24 hrs post infection (Rvb = 3 days)
Antiplasmodial activity against GFP-transfected Plasmodium berghei ANKA infected in NMRI mouse assessed as mean survival day at 200 mg/kg, po administered 24 hrs post infection (Rvb = 3 days)