| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3406502 | B | Inhibition of multidrug resistance efflux pump in Escherichia coli assessed as concentration required to reduce levofloxacin MIC by 4-fold by checkerboard assay | Escherichia coli | 61 | assay format | Scientific Literature | ||
| 2. | ALA3406503 | B | Inhibition of multidrug resistance efflux pump in wild-type Escherichia coli AB1157 assessed as concentration required to reduce piperacillin MIC by 4-fold by checkerboard assay | Escherichia coli | 61 | assay format | Scientific Literature | ||
| 3. | ALA3406506 | A | Cytotoxicity against human HeLa cells | Homo sapiens | 51 | cell-based format | Scientific Literature | ||
| 4. | ALA3406507 | F | Antibacterial activity against Escherichia coli at 100 uM | Escherichia coli | 61 | organism-based format | Scientific Literature | ||
| 5. | ALA3406508 | B | Inhibition of lactose permease-dependent [3H]TMG uptake in Escherichia coli HN1157 up to 20 uM | Escherichia coli | 61 | assay format | Scientific Literature | ||
| 6. | ALA3406509 | B | Inhibition of lactose permease in Escherichia coli HN1157 assessed as [3H]TMG accumulation up to 20 uM relative to control | Escherichia coli | 9 | assay format | Scientific Literature | ||
| 7. | ALA3406510 | F | Effect on outer membrane permeability in AcrAB-deficient Escherichia coli HN1159 assessed as influx of nitrocefin at 20 uM | Escherichia coli | 10 | organism-based format | Scientific Literature | ||
| 8. | ALA3406511 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining at 25 uM after 60 mins by HPLC analysis in presence of NADPH | Mus musculus | 14 | assay format | Scientific Literature | ||
| 9. | ALA3406512 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 25 uM after 60 mins by HPLC analysis in presence of NADPH | Homo sapiens | 14 | assay format | Scientific Literature | ||
| 10. | ALA3406513 | A | Inhibition of mouse liver microsome CYP3A4 at 3 uM after 10 mins by luminescence assay | Mus musculus | 14 | assay format | Scientific Literature | ||
| 11. | ALA3406514 | P | Aqueous solubility of the compound by nephlometric method | 14 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA3406515 | F | Antimicrobial activity against Enterobacteriaceae | Enterobacteriaceae | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4026358 | F | Potentiation of ciprofloxacin induced-antimicrobial activity against Escherichia coli AB1157 assessed as fold reduction in ciprofloxacin MIC at 12.5 uM by broth microdilution method | Escherichia coli | 1 | assay format | Scientific Literature | ||
| 14. | ALA4026359 | F | Potentiation of levofloxacin induced-antimicrobial activity against Escherichia coli AB1157 assessed as fold reduction in levofloxacin MIC at 12.5 uM by broth microdilution method | Escherichia coli | 1 | assay format | Scientific Literature | ||
| 15. | ALA4026360 | F | Potentiation of piperacillin induced-antimicrobial activity against Escherichia coli AB1157 assessed as fold reduction in piperacillin MIC at 12.5 uM by broth microdilution method | Escherichia coli | 1 | assay format | Scientific Literature | ||
| 16. | ALA4026361 | F | Potentiation of 0.016 ug/ml ciprofloxacin induced-antimicrobial activity against Escherichia coli AB1157 assessed as fold reduction in cell viability at 3.13 uM after 4 hrs by time kill assay | Escherichia coli | 1 | assay format | Scientific Literature | ||
| 17. | ALA4296184 | F | Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020); MIC in CAMBH media, using NBS plates, by OD(600) | Staphylococcus aureus | 4,588 | organism-based format | CO-ADD antimicrobial screening data | ||
| 18. | ALA4296185 | F | Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CAMBH media using NBS plates, by OD(600) | Escherichia coli | 4,585 | organism-based format | CO-ADD antimicrobial screening data | ||
| 19. | ALA4296186 | F | Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); MIC in CAMBH media using NBS plates, by OD(600) | Klebsiella pneumoniae | 6,160 | organism-based format | CO-ADD antimicrobial screening data | ||
| 20. | ALA4296187 | F | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC in CAMBH media using NBS plates, by OD(600) | Pseudomonas aeruginosa | 24,161 | organism-based format | CO-ADD antimicrobial screening data |
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