# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3405046 | B | Inhibition of Orai-mediated calcium entry in human Jurkat E6-1 cells after 1 hr by FLIPR assay | Homo sapiens | 23 | ALA3399948 | cell-based format | Scientific Literature | |
2. | ALA3405047 | B | Inhibition of Orai channel in phytohemagglutinin-stimulated human Jurkat E6-1 cells assessed as NFAT-induced transcription measured as IL-2 level after 20 hrs by ELISA | Homo sapiens | 23 | ALA3399948 | cell-based format | Scientific Literature | |
3. | ALA3405048 | B | Inhibition of human Orai1/STIM1 expressed in HEK293 cells assessed as inhibition of channel-mediated calcium current by electrophysiology assay in presence of 10 mM EGTA | Homo sapiens | 3 | ALA3399948 | cell-based format | Scientific Literature | |
4. | ALA3405049 | F | Inhibition of degranulation in human LAD2 cells assessed as inhibition of IgE-induced beta-hexosaminidase release preincubated for 30 mins by p-nitrophenyl-N-acetyl-D-glucosamide-based spectrophotometric assay | Homo sapiens | 3 | ALA3399948 | cell-based format | Scientific Literature | |
5. | ALA3405050 | F | Inhibition of IL2 secretion in rat whole blood after 24 hrs by Rat IL-2 DuoSet assay | Rattus norvegicus | 3 | ALA3399948 | tissue-based format | Scientific Literature | |
6. | ALA3405051 | A | Cytotoxicity against CHO cells | Cricetulus griseus | 3 | ALA3399948 | cell-based format | Scientific Literature | |
7. | ALA3405052 | A | Drug metabolism in rat liver microsomes at 5 uM after 30 mins in presence of NADPH | Rattus norvegicus | 3 | ALA3399948 | assay format | Scientific Literature | |
8. | ALA3405053 | A | Drug metabolism in human liver microsomes at 5 uM after 30 mins in presence of NADPH | Homo sapiens | 3 | ALA3399948 | assay format | Scientific Literature | |
9. | ALA3405054 | A | Passive permeability of the compound at 20 uM by PAMPA | 3 | ALA3399948 | assay format | Scientific Literature | ||
10. | ALA3405055 | A | Terminal half life in Wistar rat at 1 mg/kg, iv | Rattus norvegicus | 2 | ALA3399948 | organism-based format | Scientific Literature | |
11. | ALA3405056 | A | AUC (0 to 24 hrs) in Wistar rat at 1 mg/kg, iv | Rattus norvegicus | 2 | ALA3399948 | organism-based format | Scientific Literature | |
12. | ALA3405057 | A | Clearance in Wistar rat at 1 mg/kg, iv | Rattus norvegicus | 2 | ALA3399948 | organism-based format | Scientific Literature | |
13. | ALA3405058 | A | Volume of distribution at steady state in Wistar rat at 1 mg/kg, iv | Rattus norvegicus | 2 | ALA3399948 | organism-based format | Scientific Literature | |
14. | ALA3405059 | A | Cmax in Wistar rat at 10 mg/kg, po | Rattus norvegicus | 2 | ALA3399948 | organism-based format | Scientific Literature | |
15. | ALA3405060 | A | AUC (0 to 24 hrs) in Wistar rat at 10 mg/kg, po | Rattus norvegicus | 2 | ALA3399948 | organism-based format | Scientific Literature | |
16. | ALA3405061 | A | Oral bioavailability in Wistar rat at 10 mg/kg | Rattus norvegicus | 2 | ALA3399948 | organism-based format | Scientific Literature | |
17. | ALA3405062 | P | Solubility of the compound in water | 5 | ALA3399948 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA3405064 | F | Antiinflammatory activity against ovalbumin-induced model of allergic inflammation in brown Norway rat assessed as inhibition of eosinophil infiltration in bronchoalveolar lavage fluid at 3 mg/kg, po bid 1 hr before and 6.5 hrs post ovalbumin challenge measured 24 hrs post challenge relative to vehicle-treated control | Rattus norvegicus | 1 | ALA3399948 | organism-based format | Scientific Literature | |
19. | ALA3405065 | F | Antiinflammatory activity against ovalbumin-induced model of allergic inflammation in brown Norway rat assessed as inhibition of eosinophil infiltration in bronchoalveolar lavage fluid at 10 mg/kg, po bid 1 hr before and 6.5 hrs post ovalbumin challenge measured 24 hrs post challenge relative to vehicle-treated control | Rattus norvegicus | 1 | ALA3399948 | organism-based format | Scientific Literature | |
20. | ALA3405066 | F | Antiinflammatory activity against ovalbumin-induced model of allergic inflammation in brown Norway rat assessed as inhibition of eosinophil infiltration in bronchoalveolar lavage fluid at 30 mg/kg, po bid 1 hr before and 6.5 hrs post ovalbumin challenge measured 24 hrs post challenge relative to vehicle-treated control | Rattus norvegicus | 1 | ALA3399948 | organism-based format | Scientific Literature |