| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3413614 | B | Displacement of [3H]R-PIA from human recombinant A1 adenosine receptor expressed in CHO cells at 10 uM after 60 mins by liquid scintillation counting | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
| 2. | ALA3413615 | B | Displacement of [3H]CGS21680 from human recombinant A2A adenosine receptor expressed in HEK293 cells at 10 uM after 60 mins by liquid scintillation counting | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
| 3. | ALA3413616 | B | Displacement of [125I]I-AB-MECA from human recombinant A3 adenosine receptor expressed in CHO cells after 60 mins by liquid scintillation counting | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
| 4. | ALA3413617 | B | Displacement of [3H]R-PIA from mouse A1 adenosine receptor expressed in CHO cells at 10 uM after 60 mins by liquid scintillation counting | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 5. | ALA3413618 | B | Displacement of [3H]CGS21680 from mouse A2A adenosine receptor expressed in HEK293 cells at 10 uM after 60 mins by liquid scintillation counting | Mus musculus | 7 | cell-based format | Scientific Literature | ||
| 6. | ALA3413619 | B | Displacement of [125I]I-AB-MECA from mouse A3 adenosine receptor expressed in HEK293 cells after 60 mins by liquid scintillation counting | Mus musculus | 14 | cell-based format | Scientific Literature | ||
| 7. | ALA3413620 | F | Antinociceptive activity in chronic constriction injury neutropathic pain CD-1 mouse model assessed as time for peak protection at 3 umol/kg, po | Mus musculus | 35 | organism-based format | Scientific Literature | ||
| 8. | ALA3413621 | F | Antinociceptive activity in chronic constriction injury neutropathic pain CD-1 mouse model assessed as maximum protection on ipsilateral hind paw at 3 umol/kg, po after 30 mins to 5 hrs post dose relative to control | Mus musculus | 35 | organism-based format | Scientific Literature | ||
| 9. | ALA3413622 | F | Antinociceptive activity in chronic constriction injury neutropathic pain CD-1 mouse model at 3 umol/kg, po after 3 hrs post dose relative to control | Mus musculus | 35 | organism-based format | Scientific Literature | ||
| 10. | ALA3413623 | F | Agonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 mins | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA3413624 | F | Agonist activity at mouse A3 adenosine receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 15 mins relative to control | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA3413625 | F | Agonist activity at human recombinant A3 adenosine receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 15 mins | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA3413626 | F | Selectivity ratio of EC50 for human recombinant A3 adenosine receptor expressed in CHO cells to EC50 for human recombinant A1 adenosine receptor expressed in CHO cells by cAMP assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA3414372 | B | Selectivity ratio of Ki for mouse A3 adenosine receptor expressed in HEK293 cells to Ki for human recombinant A3 adenosine receptor expressed in CHO cells | 12 | cell-based format | Scientific Literature | |||
| 15. | ALA3414373 | B | Selectivity ratio of Ki for mouse A3 adenosine receptor expressed in HEK293 cells to Ki for mouse A1 adenosine receptor expressed in CHO cells | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 16. | ALA3414374 | B | Selectivity ratio of Ki for mouse A3 adenosine receptor expressed in HEK293 cells to Ki for mouse A2A adenosine receptor expressed in HEK293 cells | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 17. | ALA3414375 | P | Aqueous solubility of the compound at pH 7.4 by pION Method | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 18. | ALA3414376 | A | Half life of the compound in simulated gastric fluid at pH 1.6 | 4 | tissue-based format | Scientific Literature | |||
| 19. | ALA3414377 | A | Half life of the compound in simulated intestinal fluid at pH 6.5 | 4 | assay format | Scientific Literature | |||
| 20. | ALA3414378 | A | Fraction unbound in human plasma at 10 uM after 5 hrs by LC-MS/MS analysis | Homo sapiens | 4 | cell-free format | Scientific Literature |
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