# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3413142 | Binding | Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis | Homo sapiens | 64 | ALA3407478 | single protein format | Scientific Literature | |
2. | ALA3413143 | Binding | Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis | Homo sapiens | 64 | ALA3407478 | cell-based format | Scientific Literature | |
3. | ALA3413144 | Physicochemical | Lipophilicity, log P of the compound at pH 7 | 33 | ALA3407478 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA3413145 | Physicochemical | Aqueous solubility of the compound | 13 | ALA3407478 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA3413146 | ADME | Permeability from basolateral to apical side in human Caco2 cells | Homo sapiens | 13 | ALA3407478 | cell-based format | Scientific Literature | |
6. | ALA3413147 | ADME | Permeability from apical to basolateral side in human Caco2 cells | Homo sapiens | 13 | ALA3407478 | cell-based format | Scientific Literature | |
7. | ALA3413306 | Binding | Inhibition of mouse KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis | Mus musculus | 5 | ALA3407478 | single protein format | Scientific Literature | |
8. | ALA3413307 | Binding | Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA3407478 | single protein format | Scientific Literature | |
9. | ALA3413308 | Binding | Inhibition of KMO in human PBMC | Homo sapiens | 5 | ALA3407478 | single protein format | Scientific Literature | |
10. | ALA3413309 | Binding | Inhibition of KMO in rat microglia cells | Rattus norvegicus | 5 | ALA3407478 | cell-based format | Scientific Literature | |
11. | ALA3871819 | Binding | Inhibition of human KMO | Homo sapiens | 51 | ALA3871283 | single protein format | Scientific Literature | |
12. | ALA5225350 | Binding | Inhibition of KMO (unknown origin) | Homo sapiens | 6 | ALA5223149 | single protein format | Scientific Literature |