# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3413038 | B | Inhibition of hedgehog signaling in mouse C3H10T1/2 cells assessed as reduction in Gli1 mRNA level at 5 uM after 24 hrs by quantitative PCR analysis relative to control | Mus musculus | 34 | ALA3407363 | cell-based format | Scientific Literature | |
2. | ALA3413039 | A | Activation of VDR in mouse C3H10T1/2 cells assessed as up-regulation of Cyp24A1 mRNA at 5 uM after 24 hrs by quantitative PCR analysis relative to control | Mus musculus | 34 | ALA3407363 | cell-based format | Scientific Literature | |
3. | ALA3413040 | B | Inhibition of hedgehog signaling in mouse C3H10T1/2 cells assessed as reduction in Gli1 mRNA level after 24 hrs by quantitative PCR analysis | Mus musculus | 15 | ALA3407363 | cell-based format | Scientific Literature | |
4. | ALA3413041 | B | Inhibition of hedgehog signaling in mouse ASZ cells assessed as reduction in Gli1 mRNA level after 24 hrs by quantitative PCR analysis | Mus musculus | 15 | ALA3407363 | cell-based format | Scientific Literature | |
5. | ALA3413043 | A | Activation of VDR in mouse ASZ cells assessed as up-regulation of Cyp24A1 mRNA at 5 uM after 24 hrs by quantitative PCR analysis relative to control | Mus musculus | 14 | ALA3407363 | cell-based format | Scientific Literature | |
6. | ALA3413044 | B | Binding affinity to full length human VDR by fluorescent displacement assay | Homo sapiens | 15 | ALA3407363 | single protein format | Scientific Literature | |
7. | ALA4384327 | B | Inhibition of Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in oxysterol-induced Gli1 mRNA expression after 24 hrs by q-PCR analysis | Mus musculus | 16 | ALA4382241 | cell-based format | Scientific Literature | |
8. | ALA4384328 | B | Activation of VDR in mouse C3H10T1/2 cells assessed as change in Cyp24A1 mRNA expression at 5 uM after 24 hrs by q-PCR analysis relative to control | Mus musculus | 18 | ALA4382241 | cell-based format | Scientific Literature | |
9. | ALA4384336 | A | Half life in human liver microsomes at 1 uM by LC-MS/MS analysis | Homo sapiens | 10 | ALA4382241 | microsome format | Scientific Literature | |
10. | ALA4384337 | A | Clearance in human liver microsomes assessed per mg protein at 1 uM by LC-MS/MS analysis | Homo sapiens | 11 | ALA4382241 | microsome format | Scientific Literature | |
11. | ALA4384338 | P | Kinetic solubility of the compound in pH 4 phosphate buffered saline | 11 | ALA4382241 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4384339 | P | Kinetic solubility of the compound in pH 7.4 phosphate buffered saline | 11 | ALA4382241 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA4384341 | B | Inhibition of Hedgehog signaling pathway in VDR-deficient mouse C3H10T1/2 cells assessed as reduction in oxysterol-induced Gli1 mRNA expression at 5 uM after 24 hrs by q-PCR analysis | Mus musculus | 3 | ALA4382241 | assay format | Scientific Literature | |
14. | ALA4384343 | B | Inhibition of Hedgehog signaling pathway in Sufu-deficient mouse C3H10T1/2 cells assessed as reduction in oxysterol-induced Gli1 mRNA expression at 5 uM after 24 hrs by q-PCR analysis | Mus musculus | 4 | ALA4382241 | assay format | Scientific Literature | |
15. | ALA4384345 | B | Inhibition of Hedgehog signaling pathway in VDR-deficient mouse C3H10T1/2 cells assessed as change in CYP24A1 mRNA expression at 5 uM after 24 hrs by q-PCR analysis | Mus musculus | 3 | ALA4382241 | assay format | Scientific Literature | |
16. | ALA4384347 | B | Inhibition of Hedgehog signaling pathway in Sufu-deficient mouse C3H10T1/2 cells assessed as change in CYP24A1 mRNA expression at 5 uM after 24 hrs by q-PCR analysis | Mus musculus | 3 | ALA4382241 | assay format | Scientific Literature | |
17. | ALA4384349 | B | Inhibition of Hedgehog signaling pathway in Sufu-deficient mouse C3H10T1/2 cells assessed as reduction in oxysterol-induced Gli1 mRNA expression after 24 hrs by q-PCR analysis | Mus musculus | 4 | ALA4382241 | assay format | Scientific Literature | |
18. | ALA4384350 | B | Inhibition of Hedgehog signaling pathway in VDR-deficient mouse C3H10T1/2 cells assessed as reduction in oxysterol-induced Gli1 mRNA expression after 24 hrs by q-PCR analysis | Mus musculus | 5 | ALA4382241 | assay format | Scientific Literature |