# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3412689 | Binding | Binding affinity to human RFC expressed in Chinese hamster PC43-10 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay | Homo sapiens | 8 | ALA3407468 | cell-based format | Scientific Literature | |
2. | ALA3412690 | ADME | Cytotoxicity against RFC-deficient Chinese hamster R2 cells assessed as growth inhibition after 96 hrs by CellTiter-Blue assay | Cricetulus griseus | 8 | ALA3407468 | cell-based format | Scientific Literature | |
3. | ALA3412691 | Binding | Binding affinity to human FRalpha expressed in Chinese hamster RT16 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay | Homo sapiens | 8 | ALA3407468 | cell-based format | Scientific Literature | |
4. | ALA3412692 | Binding | Binding affinity to human PCFT expressed in Chinese hamster R2/PCFT4 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay | Homo sapiens | 8 | ALA3407468 | cell-based format | Scientific Literature | |
5. | ALA3412693 | ADME | Cytotoxicity against PCFT-deficient Chinese hamster R2(VC) cells assessed as growth inhibition after 96 hrs by CellTiter-Blue assay | Cricetulus griseus | 8 | ALA3407468 | cell-based format | Scientific Literature | |
6. | ALA3412694 | Functional | Antiproliferative activity against human KB cells expressing RFC/FRalpha/PCFT after 96 hrs by CellTiter-Blue assay | Homo sapiens | 8 | ALA3407468 | cell-based format | Scientific Literature | |
7. | ALA3412695 | Functional | Antiproliferative activity against human KB cells expressing RFC/FRalpha/PCFT after 96 hrs by CellTiter-Blue assay in presence of 200 nM folic acid | Homo sapiens | 2 | ALA3407468 | cell-based format | Scientific Literature | |
8. | ALA3412697 | Binding | Inhibition of GARFTase/AICARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as cell growth inhibition at 1 to 1000 nM after 96 hrs by CellTiter-Blue assay in presence of 60 uM adenosine | Homo sapiens | 4 | ALA3407468 | cell-based format | Scientific Literature | |
9. | ALA3412860 | Binding | Inhibition of GARFTase/AICARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as cell growth inhibition at 1 to 1000 nM after 96 hrs by CellTiter-Blue assay in presence of 10 uM thymidine | Homo sapiens | 4 | ALA3407468 | cell-based format | Scientific Literature | |
10. | ALA3412861 | Binding | Inhibition of AICARFTase in human KB cells expressing RFC/FRalpha/PCFT assessed as cell growth inhibition at 1 to 1000 nM after 96 hrs by CellTiter-Blue assay in presence of 320 uM AICA | Homo sapiens | 4 | ALA3407468 | cell-based format | Scientific Literature |