# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3413637 | B | Inhibition of human recombinant myostatin pre-incubated with compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated downstream transcriptional response by myostatin-responsive (CAGA)12-luciferase reporter gene assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
2. | ALA3413639 | B | Inhibition of human recombinant myostatin pre-incubated with 30 uM compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated Smad2 phosphorylation by Western blotting method | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
3. | ALA3413640 | F | Effect on transcriptional response in human HepG2 cells at 30 uM in absence of myostatin by myostatin-responsive (CAGA)12-luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
4. | ALA3413641 | B | Inhibition of human recombinant myostatin pre-incubated with 30 uM compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated downstream transcriptional response by myostatin-responsive (CAGA)12-luciferase reporter gene assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
5. | ALA3413642 | B | Binding affinity to recombinant myostatin (unknown origin) by surface plasmon resonance assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
6. | ALA3413786 | F | Increase in muscle mass in mdx mouse model of Duchenne muscular dystrophy model at 0.75 mM dosed intramuscularly into tibialis anterior muscle followed by treatment repetition after 2 weeks by dosing in same muscle and measured 4 weeks after last treatment relative to untreated control | Mus musculus | 1 | organism-based format | Scientific Literature |