# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3411252 | B | Inhibition of human KLF10 expressed in human HeLa cells assessed as reduction in transcriptional activity at 100 uM after 24 hrs by CACCC-responsive promoter driven TK-luciferase reporter gene assay | Homo sapiens | 40 | cell-based format | Scientific Literature | ||
2. | ALA3411253 | B | Inhibition of human KLF10 expressed in human HeLa cells assessed as reduction in transcriptional activity after 24 hrs by CACCC-responsive promoter driven TK-luciferase reporter gene assay | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
3. | ALA3411254 | B | Inhibition of KLF10 (unknown origin) binding to DNA at 40 uM incubated for 4 hrs followed by biotin-labeled probes addition and incubated for another 1 hr by electromobility gel shift assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
4. | ALA3411255 | B | Inhibition of KLF10 (unknown origin) binding to DNA at 8 uM incubated for 4 hrs followed by biotin-labeled probes addition and incubated for another 1 hr by electromobility gel shift assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
5. | ALA3411257 | B | Inhibition of KLF1 (unknown origin) binding to DNA at 40 uM incubated for 4 hrs followed by biotin-labeled probes addition and incubated for another 1 hr by electromobility gel shift assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
6. | ALA3411258 | B | Inhibition of KLF1 (unknown origin) binding to DNA at 8 uM incubated for 4 hrs followed by biotin-labeled probes addition and incubated for another 1 hr by electromobility gel shift assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
7. | ALA3411259 | F | Inhibition of mouse T regulatory cell differentiation assessed as inhibition of TGFbeta1-induced conversion of CD4(+) and CD25(-) cells to CD4(+) and CD25(+) cells incubated for 3 days by flow cytometry | Mus musculus | 3 | assay format | Scientific Literature | ||
8. | ALA3411260 | F | Inhibition of Foxp3 gene expression in mouse T regulatory cells at 50 uM measured during TGFbeta1-induced conversion of CD4(+) and CD25(-) cells to CD4(+) and CD25(+) cells incubated for 3 days by real-time quantitative PCR method | Mus musculus | 3 | cell-based format | Scientific Literature | ||
9. | ALA4419303 | B | Inhibition of human KLF10 expressed in human HeLa cells assessed as reduction in KLF10-mediated transcriptional activity at 100 uM incubated for 24 hrs by luciferase reporter assay relative to control | Homo sapiens | 33 | cell-based format | Patent Bioactivity Data | ||
10. | ALA4419304 | B | Inhibition of human KLF10 expressed in human HeLa cells assessed as reduction in KLF10-mediated transcriptional activity incubated for 24 hrs by luciferase reporter assay | Homo sapiens | 33 | cell-based format | Patent Bioactivity Data | ||
11. | ALA4419305 | B | Inhibition of KLF10 (unknown origin) binding to double-stranded DNA containing KLF10 consensus binding site at 40 uM by by electromobility gel shift assay relative to control | Homo sapiens | 2 | single protein format | Patent Bioactivity Data | ||
12. | ALA4419306 | B | Inhibition of KLF10 (unknown origin) binding to double-stranded DNA containing KLF10 consensus binding site at 8 uM by by electromobility gel shift assay relative to control | Homo sapiens | 3 | single protein format | Patent Bioactivity Data | ||
13. | ALA4419308 | B | Inhibition of GST-tagged KLF1 (unknown origin) binding to double-stranded DNA at 8 uM by by electromobility gel shift assay relative to control | Homo sapiens | 2 | single protein format | Patent Bioactivity Data | ||
14. | ALA4419309 | B | Inhibition of GST-tagged KLF1 (unknown origin) binding to double-stranded DNA at 40 uM by by electromobility gel shift assay relative to control | Homo sapiens | 2 | single protein format | Patent Bioactivity Data | ||
15. | ALA4419310 | F | Inhibition of T regulatory cell differentiation in mouse CD4+CD25- T cells assessed as reduction in conversion of CD4+CD25- T cells to CD4+CD25+ T regs cells incubated for 5 days by flow cytometry relative to control | Mus musculus | 3 | cell-based format | Patent Bioactivity Data | ||
16. | ALA4419311 | B | Inhibition of KLF10 in mouse CD4+CD25- T cells assessed as reduction in Foxp3 mRNA expression at 50 uM incubated for 5 days by real time qPCR analysis relative to control | Mus musculus | 3 | cell-based format | Patent Bioactivity Data | ||
17. | ALA4419315 | B | Inhibition of KLF10 in mouse CD4+CD25- T cells assessed as reduction in Foxp3 mRNA expression incubated for 5 days by real time qPCR analysis relative to control | Mus musculus | 3 | cell-based format | Patent Bioactivity Data | ||
18. | ALA4419316 | B | Inhibition of KLF10 in mouse CD4+CD25- T cells assessed as reduction in checkpoint markers on iTregs by measuring PD1 expression level (Rvb = 87.4%) | Mus musculus | 2 | cell-based format | Patent Bioactivity Data | ||
19. | ALA4419317 | B | Inhibition of KLF10 in mouse CD4+CD25- T cells assessed as reduction in checkpoint markers on iTregs by measuring PDL1 expression level (Rvb = 74.8%) | Mus musculus | 2 | cell-based format | Patent Bioactivity Data | ||
20. | ALA4419318 | B | Inhibition of KLF10 in mouse CD4+CD25- T cells assessed as reduction in checkpoint markers on iTregs by measuring CTLA4 expression level (Rvb = 95.9%) | Mus musculus | 2 | cell-based format | Patent Bioactivity Data |