# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3421440 | B | Inhibition of human EZH2 using SAM and histone H3 (16 to 30) as substrate preincubated for 30 mins followed by substrate addition measured after 90 mins by flash plate assay | Homo sapiens | 2 | ALA3414551 | single protein format | Scientific Literature | |
2. | ALA3772956 | B | Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assay | Homo sapiens | 48 | ALA3769394 | single protein format | Scientific Literature | |
3. | ALA3772958 | B | Inhibition of methyltransferase activity of EZH2 in human G401 cells assessed as H3K27 trimethylation after 4 hrs by ELISA | Homo sapiens | 8 | ALA3769394 | cell-based format | Scientific Literature | |
4. | ALA3772959 | A | Clearance in mouse at 2 mg/kg, iv and 10 mg/kg, po by LC-MS/MS analysis | Mus musculus | 8 | ALA3769394 | organism-based format | Scientific Literature | |
5. | ALA3772960 | A | AUC in mouse at 2 mg/kg, iv and 10 mg/kg, po by LC-MS/MS analysis | Mus musculus | 8 | ALA3769394 | organism-based format | Scientific Literature | |
6. | ALA3772961 | A | Volume of distribution at steady state in mouse at 2 mg/kg, iv and 10 mg/kg, po by LC-MS/MS analysis | Mus musculus | 8 | ALA3769394 | organism-based format | Scientific Literature | |
7. | ALA3772962 | A | Oral bioavailability in mouse at 10 mg/kg by LC-MS/MS analysis | Mus musculus | 8 | ALA3769394 | organism-based format | Scientific Literature | |
8. | ALA4735334 | B | Inhibition of wild type EZH2 in human PRC2 complex using S-adenosylmethionine and biotinylated histone peptides as substrate | Homo sapiens | 3 | ALA4732117 | single protein format | Scientific Literature | |
9. | ALA5123926 | B | Inhibition of EZH2 (unknown origin) | Homo sapiens | 42 | ALA5120864 | single protein format | Scientific Literature | |
10. | ALA5123927 | B | Inhibition of PRC2 (unknown origin) assessed as inhibition constant | Homo sapiens | 3 | ALA5120864 | assay format | Scientific Literature |