| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3418455 | B | Inhibition of N-terminal FLAG tagged full-length human EZH2 expressed in baculovirus infected Sf9 cells using H3K27 as substrate after 120 mins by mass spectrophotometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA3418456 | B | Inhibition of N-terminal FLAG tagged human EZH2 Y641F mutant expressed in baculovirus infected Sf9 cells using H3K27 as substrate after 120 mins by mass spectrophotometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA3418457 | B | Inhibition of N-terminal FLAG tagged full-length human EZH2 expressed in baculovirus infected Sf9 cells using H3K27 as substrate in presence of SAM | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA3418458 | B | Selectivity ratio of IC50 for recombinant human G9a catalytic domain to IC50 for N-terminal FLAG tagged full-length human EZH2 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 5. | ALA3418459 | B | Selectivity ratio of IC50 for recombinant human SUV39H2 catalytic domain to IC50 for N-terminal FLAG tagged full-length human EZH2 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 6. | ALA3418460 | B | Selectivity ratio of IC50 for recombinant human MLL catalytic domain to IC50 for N-terminal FLAG tagged full-length human EZH2 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 7. | ALA3418461 | B | Selectivity ratio of IC50 for recombinant human SETD2 catalytic domain to IC50 for N-terminal FLAG tagged full-length human EZH2 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA3418462 | B | Selectivity ratio of IC50 for recombinant human SETD7 catalytic domain to IC50 for N-terminal FLAG tagged full-length human EZH2 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA3418463 | B | Selectivity ratio of IC50 for recombinant human SETD8 catalytic domain to IC50 for N-terminal FLAG tagged full-length human EZH2 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA3418464 | B | Selectivity ratio of IC50 for recombinant full-length human SMYD2 to IC50 for N-terminal FLAG tagged full-length human EZH2 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA3418465 | B | Selectivity ratio of IC50 for recombinant human WHSC1L1 catalytic domain to IC50 for N-terminal FLAG tagged full-length human EZH2 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA3418466 | B | Selectivity ratio of IC50 for recombinant human CARM1 catalytic domain to IC50 for N-terminal FLAG tagged full-length human EZH2 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA3418467 | B | Selectivity ratio of IC50 for recombinant human DOT1L catalytic domain to IC50 for N-terminal FLAG tagged full-length human EZH2 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA3418468 | B | Selectivity ratio of IC50 for recombinant human EZH1 to IC50 for N-terminal FLAG tagged full-length human EZH2 | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA3418469 | B | Inhibition of wild-type EZH2 in human G401 cells assessed as upregulation of p16 mRNA expression at 10 uM after 5 days by qPCR analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4303805 | F | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging | Homo sapiens | 5,612 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | ||
| 17. | ALA4401277 | B | Inhibition of EZH2 Y641F mutant (unknown origin) using dimethylated H3K27 as substrate | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA4401279 | B | Inhibition of EZH2 (unknown origin) using unmethylated H3K27 (21 to 44 residues) as substrate | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA4495582 | F | SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate | Severe acute respiratory syndrome coronavirus 2 | 7,212 | assay format | SARS-CoV-2 Screening Data 2020-21 | ||
| 20. | ALA4513082 | F | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging | Chlorocebus sabaeus | 7,212 | organism-based format | SARS-CoV-2 Screening Data 2020-21 |
The page will load shortly, Thanks for your patience!