| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3420648 | F | Antiarthritic activity in CII-induced DBA/1J mouse arthritic model assessed as decrease in chronic inflammation at 50 mg/kg, ip measured 10 days post second CII booster by Hematoxylin and eosin staining relative to CII-treated control | Mus musculus | 1 | ALA3414458 | organism-based format | Scientific Literature | |
| 2. | ALA3420649 | F | Antiarthritic activity in CII-induced DBA/1J mouse arthritic model assessed as decrease in abcess formation at 50 mg/kg, ip measured 10 days post second CII booster by Hematoxylin and eosin staining relative to CII-treated control | Mus musculus | 1 | ALA3414458 | organism-based format | Scientific Literature | |
| 3. | ALA3420650 | F | Antiarthritic activity in CII-induced DBA/1J mouse arthritic model assessed as decrease in fibrosis at 50 mg/kg, ip measured 10 days post second CII booster by Hematoxylin and eosin staining relative to CII-treated control | Mus musculus | 1 | ALA3414458 | organism-based format | Scientific Literature | |
| 4. | ALA3420651 | F | Antiarthritic activity in CII-induced DBA/1J mouse arthritic model assessed as decrease in periarticular erosion at 50 mg/kg, ip measured 10 days post second CII booster by Hematoxylin and eosin staining relative to CII-treated control | Mus musculus | 1 | ALA3414458 | organism-based format | Scientific Literature | |
| 5. | ALA3420652 | F | Downregulation of COX-2 expression in ankle tissue of CII-induced DBA/1J mouse arthritic model at 25 to 50 mg/kg, ip measured 10 days post second CII booster by immunoblot analysis | Mus musculus | 1 | ALA3414458 | organism-based format | Scientific Literature | |
| 6. | ALA3420653 | F | Downregulation of iNOS expression in ankle tissue of CII-induced DBA/1J mouse arthritic model at 25 to 50 mg/kg, ip measured 10 days post second CII booster by immunoblot analysis | Mus musculus | 1 | ALA3414458 | organism-based format | Scientific Literature | |
| 7. | ALA3420654 | A | AUClast in rat at 10 mg/kg, ip | Rattus norvegicus | 1 | ALA3414458 | organism-based format | Scientific Literature | |
| 8. | ALA3420655 | A | Cmax in rat at 10 mg/kg, ip | Rattus norvegicus | 1 | ALA3414458 | organism-based format | Scientific Literature | |
| 9. | ALA3420656 | A | Half life in rat at 10 mg/kg, ip | Rattus norvegicus | 1 | ALA3414458 | organism-based format | Scientific Literature | |
| 10. | ALA3420657 | A | Bioavailability in rat at 10 mg/kg, ip | Rattus norvegicus | 1 | ALA3414458 | organism-based format | Scientific Literature | |
| 11. | ALA3420658 | A | AUClast in rat at 20 mg/kg, iv | Rattus norvegicus | 1 | ALA3414458 | organism-based format | Scientific Literature | |
| 12. | ALA3420659 | A | Terminal half life in rat at 20 mg/kg, iv | Rattus norvegicus | 1 | ALA3414458 | organism-based format | Scientific Literature | |
| 13. | ALA3420660 | B | Competitive antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromide uptake at 0.1 to 1 uM after 2 hrs by fluorescence assay in presence of BzATP | Homo sapiens | 1 | ALA3414458 | cell-based format | Scientific Literature | |
| 14. | ALA3418717 | B | Antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromide uptake after 2 hrs by fluorescence assay | Homo sapiens | 42 | ALA3414458 | cell-based format | Scientific Literature | |
| 15. | ALA3418719 | B | Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins followed by BzATP induction measured after 30 mins by ELISA | Homo sapiens | 26 | ALA3414458 | cell-based format | Scientific Literature | |
| 16. | ALA3418720 | B | Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release at 1 uM preincubated for 30 mins followed by BzATP induction measured after 30 mins by ELISA relative to control | Homo sapiens | 26 | ALA3414458 | cell-based format | Scientific Literature | |
| 17. | ALA3418721 | B | Antagonist activity at recombinant mouse P2X1 receptor overexpressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 10 uM preincubated for 20 mins followed by ATP induction by two-electrode voltage clamping method relative to control | Mus musculus | 1 | ALA3414458 | cell-based format | Scientific Literature | |
| 18. | ALA3418722 | B | Antagonist activity at recombinant human P2X3 receptor overexpressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current at 10 uM preincubated for 20 mins followed by ATP induction by two-electrode voltage clamping method relative to control | Homo sapiens | 1 | ALA3414458 | cell-based format | Scientific Literature | |
| 19. | ALA3418723 | B | Antagonist activity at P2X7 receptor in LPS-primed mouse J774.A1 cells assessed as inhibition of ATP-induced IL-1beta release after 30 mins by ELISA | Mus musculus | 2 | ALA3414458 | cell-based format | Scientific Literature | |
| 20. | ALA3418724 | B | Antagonist activity at P2X7 receptor in neuropathic rat dorsal horn assessed as inhibition of long term potentiation-induced neropathic pain at 20 uM relative to control | Rattus norvegicus | 2 | ALA3414458 | single protein format | Scientific Literature |
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