# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3420275 | B | Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA | Homo sapiens | 27 | ALA3414430 | cell-based format | Scientific Literature | |
2. | ALA3420276 | B | Inhibition of HDAC1 (unknown origin) using RHKK(Ac)AMC as substrate | Homo sapiens | 27 | ALA3414430 | single protein format | Scientific Literature | |
3. | ALA3420277 | B | Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrate | Homo sapiens | 27 | ALA3414430 | single protein format | Scientific Literature | |
4. | ALA3420550 | B | Inhibition of HDAC8 (unknown origin) using RHK(Ac)K(Ac)AMC as substrate | Homo sapiens | 27 | ALA3414430 | single protein format | Scientific Literature | |
5. | ALA3420551 | P | Solubility of the compound in PBS measured after overnight incubation by LYSA assay | 27 | ALA3414430 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA3420552 | A | Intrinsic clearance in human liver microsomes at 1 uM preincubated for 10 mins followed by NADPH addition measured over 30 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA3414430 | assay format | Scientific Literature | |
7. | ALA3420553 | A | Intrinsic clearance in mouse liver microsomes at 1 uM preincubated for 10 mins followed by NADPH addition measured over 30 mins by LC-MS/MS analysis | Mus musculus | 5 | ALA3414430 | assay format | Scientific Literature | |
8. | ALA3420554 | B | Inhibition of HDAC1/HDAC2/HDAC3 in human HeLa cells assessed as induction of p21 gene expression at 10 uM after 15 hrs by luciferase reporter gene assay relative to HDAC1 inhibitor SNDX-275 | Homo sapiens | 8 | ALA3414430 | cell-based format | Scientific Literature | |
9. | ALA3420557 | B | Inhibition of HDAC6 in human NCI-H929 cells assessed as induction of tubulin acetylation after 24 hrs by Western blot analysis | Homo sapiens | 6 | ALA3414430 | cell-based format | Scientific Literature | |
10. | ALA3420558 | A | Plasma clearance in ICR mouse | Mus musculus | 6 | ALA3414430 | organism-based format | Scientific Literature | |
11. | ALA3420560 | A | AUC (0 to infinity) in ICR mouse at 25 mg/kg, iv | Mus musculus | 1 | ALA3414430 | organism-based format | Scientific Literature | |
12. | ALA3420562 | A | AUC (0 to infinity) in ICR mouse at 50 mg/kg, po | Mus musculus | 2 | ALA3414430 | organism-based format | Scientific Literature | |
13. | ALA3420783 | A | Oral bioavailability in ICR mouse at 50 mg/kg | Mus musculus | 2 | ALA3414430 | organism-based format | Scientific Literature | |
14. | ALA3420793 | A | Half life in ICR mouse at 25 mg/kg, iv | Mus musculus | 1 | ALA3414430 | organism-based format | Scientific Literature | |
15. | ALA3420794 | A | Cmax in ICR mouse at 50 mg/kg, po | Mus musculus | 2 | ALA3414430 | organism-based format | Scientific Literature |