# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3418688 | B | Inhibition of B-Raf V600E mutant (unknown origin) assessed as inhibition of phosphorylation of peptide substrate | Homo sapiens | 4 | ALA3414549 | single protein format | Scientific Literature | |
2. | ALA3418689 | B | Inhibition of wild type B-Raf (unknown origin) assessed as inhibition of phosphorylation of peptide substrate | Homo sapiens | 4 | ALA3414549 | single protein format | Scientific Literature | |
3. | ALA3418690 | B | Binding affinity to B-Raf V600E mutant (unknown origin) | Homo sapiens | 4 | ALA3414549 | single protein format | Scientific Literature | |
4. | ALA3418691 | B | Binding affinity to wild type B-Raf (unknown origin) | Homo sapiens | 4 | ALA3414549 | single protein format | Scientific Literature | |
5. | ALA3419330 | B | Inhibition of B-Raf V600E mutant in human A375 cells assessed as phosphorylation of ERK | Homo sapiens | 4 | ALA3414549 | cell-based format | Scientific Literature | |
6. | ALA3419331 | F | Inhibition of cell proliferation in human A375 cells expressing B-Raf V600E mutant after 96 hrs by MTT assay | Homo sapiens | 4 | ALA3414549 | cell-based format | Scientific Literature | |
7. | ALA3419332 | F | Inhibition of cell proliferation in human SW620 cells expressing wild type B-Raf after 96 hrs by MTT assay | Homo sapiens | 4 | ALA3414549 | cell-based format | Scientific Literature | |
8. | ALA3419333 | B | Inhibition of phosphorylation of MEK level in human SW620 cells expressing wild type B-Raf at 30 nM to 3 microM after 48 hrs by immunoblotting analysis | Homo sapiens | 2 | ALA3414549 | cell-based format | Scientific Literature | |
9. | ALA3419334 | B | Inhibition of phosphorylation of ERK level in human SW620 cells expressing wild type B-Raf at 30 nM to 3 microM after 48 hrs by immunoblotting analysis | Homo sapiens | 2 | ALA3414549 | cell-based format | Scientific Literature | |
10. | ALA3419337 | B | Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as SPQKPIVR accessible protease cleavage peptide level by LC-MS/MS analysis relative to control | Homo sapiens | 7 | ALA3414549 | single protein format | Scientific Literature | |
11. | ALA3419338 | B | Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as VFLPNK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control | Homo sapiens | 7 | ALA3414549 | single protein format | Scientific Literature | |
12. | ALA3419339 | B | Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as 7VVPAR accessible protease cleavage peptide level by LC-MS/MS analysis relative to control | Homo sapiens | 7 | ALA3414549 | single protein format | Scientific Literature | |
13. | ALA3419340 | B | Activation of tumorigenic wild type B-Raf in human IPC-298 cells with Ras mutation assessed as phosphorylation of ERK | Homo sapiens | 4 | ALA3414549 | cell-based format | Scientific Literature | |
14. | ALA3419722 | B | Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as DSLKK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control | Homo sapiens | 7 | ALA3414549 | single protein format | Scientific Literature | |
15. | ALA3419723 | B | Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as SIPIPQPFRPADEDHR accessible protease cleavage peptide level by LC-MS/MS analysis relative to control | Homo sapiens | 7 | ALA3414549 | single protein format | Scientific Literature | |
16. | ALA3419724 | B | Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as GDGGSTTGLSATPPASLPGSLTNVK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control | Homo sapiens | 7 | ALA3414549 | single protein format | Scientific Literature | |
17. | ALA3419725 | B | Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as DSSDDWEIPDGQITVGQR accessible protease cleavage peptide level by LC-MS/MS analysis relative to control | Homo sapiens | 7 | ALA3414549 | single protein format | Scientific Literature | |
18. | ALA3419726 | B | Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as IGSGSFGTVYK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control | Homo sapiens | 7 | ALA3414549 | single protein format | Scientific Literature | |
19. | ALA3419727 | B | Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as WHGDVAVK accessible protease cleavage peptide level by LC-MS/MS analysis relative to control | Homo sapiens | 7 | ALA3414549 | single protein format | Scientific Literature | |
20. | ALA3419728 | B | Binding affinity to recombinant human full-length wild type B-Raf (unknown origin) assessed as NEVGVLR accessible protease cleavage peptide level by LC-MS/MS analysis relative to control | Homo sapiens | 7 | ALA3414549 | single protein format | Scientific Literature |