# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3419139 | B | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenzyme A production after 45 mins by CPM based HTS assay | Saccharomyces cerevisiae | 107 | ALA3414544 | single protein format | Scientific Literature | |
2. | ALA3419140 | B | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenzyme A production after 45 mins by CoA-based HTS counter screen assay | Saccharomyces cerevisiae | 104 | ALA3414544 | single protein format | Scientific Literature | |
3. | ALA3419141 | B | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 assessed as H3K56 acetylated product at 125 uM after 45 mins by Slot bolt inhibiton assay | Saccharomyces cerevisiae | 104 | ALA3414544 | single protein format | Scientific Literature | |
4. | ALA3419142 | B | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 assessed as H3K27 acetylated product at 125 uM after 45 mins by Slot bolt inhibiton assay | Saccharomyces cerevisiae | 104 | ALA3414544 | single protein format | Scientific Literature | |
5. | ALA3419143 | P | Fluorescence quenching assessed as fluorescence signal reduction at 10 uM after 10 mins | 104 | ALA3414544 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA3419144 | P | Fluorescence quenching in HTS buffer assessed as fluorescence signal reduction at 10 uM after 10 mins | 104 | ALA3414544 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA3419553 | P | Fluorescence quenching in HTS buffer with 7.5 uM CoA assessed as fluorescence signal reduction at 10 uM after 10 mins | 104 | ALA3414544 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA3419557 | B | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting | Saccharomyces cerevisiae | 22 | ALA3414544 | single protein format | Scientific Literature | |
9. | ALA3419558 | B | Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting | Homo sapiens | 22 | ALA3414544 | single protein format | Scientific Literature | |
10. | ALA3419559 | B | Inhibition of yeast histone acetyltransferase Gcn5-Ada2-Ada3 complex using tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting | Saccharomyces cerevisiae | 22 | ALA3414544 | single protein format | Scientific Literature | |
11. | ALA3419560 | B | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting in presence of 1 mM DTT | Saccharomyces cerevisiae | 22 | ALA3414544 | single protein format | Scientific Literature | |
12. | ALA3419561 | B | Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting in presence of 1 mM DTT | Homo sapiens | 22 | ALA3414544 | single protein format | Scientific Literature | |
13. | ALA3419562 | B | Inhibition of yeast histone acetyltransferase Gcn5-Ada2-Ada3 complex using tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting in presence of 1 mM DTT | Saccharomyces cerevisiae | 22 | ALA3414544 | single protein format | Scientific Literature | |
14. | ALA3419578 | P | Fluorescence quenching in HTS buffer with 20 uM 7-diethylamino-3-(4'-maleimidyl-phenyl)-4-methylcoumarin assessed as fluorescence signal reduction at 10 uM after 10 mins | 104 | ALA3414544 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA4269302 | B | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD | Cryptococcus neoformans | 16 | ALA4265991 | assay format | Scientific Literature | |
16. | ALA4269303 | B | Inhibition of recombinant human His-tagged IMPDH1 expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD | Homo sapiens | 16 | ALA4265991 | assay format | Scientific Literature | |
17. | ALA4269304 | B | Inhibition of recombinant human His-tagged IMPDH2 expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD | Homo sapiens | 16 | ALA4265991 | assay format | Scientific Literature | |
18. | ALA4269307 | F | Antifungal activity against Candida albicans after 24 hrs by two fold serial dilution method | Candida albicans | 17 | ALA4265991 | organism-based format | Scientific Literature | |
19. | ALA4269308 | F | Antifungal activity against Cryptococcus neoformans after 24 hrs by resazurin-dye based two fold serial dilution method | Cryptococcus neoformans | 17 | ALA4265991 | organism-based format | Scientific Literature | |
20. | ALA4269309 | A | Cytotoxicity against HEK293 cells after 24 hrs by resazurin dye-based fluorescence analysis | Homo sapiens | 16 | ALA4265991 | cell-based format | Scientific Literature |