| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3418219 | B | Inhibition of human recombinant ERAP1 expressed in baculovirus infected Sf9 cells using L-leucine-7-amido-4-methyl coumarin as substrate after 5 to 10 mins by fluorescence assay | Homo sapiens | 41 | ALA3414429 | cell-based format | Scientific Literature | |
| 2. | ALA3418221 | B | Inhibition of human recombinant ERAP2 expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-arginyl-7-amido-4-methyl coumarin as substrate after 5 to 10 mins by fluorescence assay | Homo sapiens | 60 | ALA3414429 | cell-based format | Scientific Literature | |
| 3. | ALA3419982 | B | Inhibition of human recombinant IRAP expressed in baculovirus infected cabbage looper ovary Hi5 cells using L-leucine-7-amido-4-methyl coumarin as substrate after 5 to 10 mins by fluorescence assay | Homo sapiens | 68 | ALA3414429 | cell-based format | Scientific Literature | |
| 4. | ALA3419985 | B | Inhibition of ERAP1 in mouse RAW264.7 cells assessed as reduction in interferon-gamma/LPS-induced phagocytosis after 24 hrs by fluorescent latex beads internalization assay | Mus musculus | 4 | ALA3414429 | cell-based format | Scientific Literature | |
| 5. | ALA3419986 | B | Inhibition of mouse recombinant IRAP using L-leucine-7-amido-4-methyl coumarin as substrate after 5 to 10 mins by fluorescence assay | Mus musculus | 1 | ALA3414429 | single protein format | Scientific Literature | |
| 6. | ALA3419987 | B | Selectivity ratio of IC50 for human recombinant IRAP to IC50 for mouse recombinant IRAP | 1 | ALA3414429 | assay format | Scientific Literature | ||
| 7. | ALA3419988 | B | Inhibition of IRAP in mouse BMDC assessed as blockade of cross-presentation by measuring IL-2 level incubated for 1 day followed by compound wash out and incubated for 6 hrs with yeast cells expressing surface ovalbumin measured 20 hrs post CD8+ T cell-induction by sandwich ELISA method | Mus musculus | 1 | ALA3414429 | cell-based format | Scientific Literature | |
| 8. | ALA3419989 | F | Blockade of cross-presentation in mouse IRAP-deficient BMDC assessed as IL-2 level incubated for 1 day followed by compound wash out and incubated for 6 hrs with yeast cells expressing surface ovalbumin measured 20 hrs post CD8+ T cell-induction by sandwich ELISA method | Mus musculus | 1 | ALA3414429 | cell-based format | Scientific Literature |
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