# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3420840 | B | Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis | Homo sapiens | 45 | ALA3414472 | cell-based format | Scientific Literature | |
2. | ALA3420841 | B | Inhibition of FLAP in calcimycin-stimulated human whole blood assessed as inhibition of LTB4 synthesis preincubated for 15 mins followed by calcimycin stimulation measured after 30 mins | Homo sapiens | 45 | ALA3414472 | single protein format | Scientific Literature | |
3. | ALA3420842 | P | Aqueous equilibrium solubility of the compound in crystalline form in citric acid/disodium phosphate buffer at pH 6.8 after 24 hrs of rotation by HPLC analysis | 11 | ALA3414472 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA3420843 | A | Inhibition of CYP2C9 in human liver microsomes using dichlofenac as substrate preincubated for 10 mins followed by NADPH addition measured after 6 mins | Homo sapiens | 5 | ALA3414472 | assay format | Scientific Literature | |
5. | ALA3420844 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition measured after 6 mins | Homo sapiens | 5 | ALA3414472 | assay format | Scientific Literature | |
6. | ALA3420848 | B | Inhibition of FLAP in calcimycin-stimulated mouse whole blood assessed as inhibition of LTB4 synthesis preincubated for 15 mins followed by calcimycin stimulation measured after 30 mins | Mus musculus | 4 | ALA3414472 | single protein format | Scientific Literature | |
7. | ALA3420849 | A | Metabolic stability in human liver microsomes at 1 uM preincubated for 10 mins followed by NADPH addition measured over 60 mins by LC/MS analysis relative to hepatic blood flow | Homo sapiens | 4 | ALA3414472 | assay format | Scientific Literature | |
8. | ALA3420850 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 10 mins followed by NADPH addition measured after 6 mins | Homo sapiens | 4 | ALA3414472 | assay format | Scientific Literature | |
9. | ALA3420851 | B | Inhibition of human ERG expressed in HEK293 cells assessed as change in tail current at 11 uM by manual patch clamp assay relative to control | Homo sapiens | 4 | ALA3414472 | cell-based format | Scientific Literature | |
10. | ALA4047400 | B | Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount method | Homo sapiens | 57 | ALA4043239 | cell-based format | Scientific Literature | |
11. | ALA4047401 | B | Inhibition of FLAP in calcimycin-stimulated human whole blood assessed as reduction in LTB4 production pretreated for 15 mins followed by calcimycin addition after 30 mins by ELISA | Homo sapiens | 57 | ALA4043239 | single protein format | Scientific Literature | |
12. | ALA4047402 | B | Inhibition of human ERG expressed in CHO cells at 11 uM at -70mV holding potential measured after 300 secs by IonWorks electrophysiology method relative to control | Homo sapiens | 7 | ALA4043239 | cell-based format | Scientific Literature | |
13. | ALA4047403 | P | Aqueous kinetic solubility of the compound at pH 7.4 | 46 | ALA4043239 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA4047404 | A | Stability in human liver microsomes at 1 uM pretreated for 10 mins followed by NADPH addition after 60 mins by LC/MS analysis relative to hepatic blood flow | Homo sapiens | 32 | ALA4043239 | assay format | Scientific Literature |