| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3420840 | B | Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis | Homo sapiens | 45 | ALA3414472 | cell-based format | Scientific Literature | |
| 2. | ALA3420841 | B | Inhibition of FLAP in calcimycin-stimulated human whole blood assessed as inhibition of LTB4 synthesis preincubated for 15 mins followed by calcimycin stimulation measured after 30 mins | Homo sapiens | 45 | ALA3414472 | single protein format | Scientific Literature | |
| 3. | ALA3420842 | P | Aqueous equilibrium solubility of the compound in crystalline form in citric acid/disodium phosphate buffer at pH 6.8 after 24 hrs of rotation by HPLC analysis | 11 | ALA3414472 | small-molecule physicochemical format | Scientific Literature | ||
| 4. | ALA3420843 | A | Inhibition of CYP2C9 in human liver microsomes using dichlofenac as substrate preincubated for 10 mins followed by NADPH addition measured after 6 mins | Homo sapiens | 5 | ALA3414472 | assay format | Scientific Literature | |
| 5. | ALA3420844 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition measured after 6 mins | Homo sapiens | 5 | ALA3414472 | assay format | Scientific Literature | |
| 6. | ALA3420848 | B | Inhibition of FLAP in calcimycin-stimulated mouse whole blood assessed as inhibition of LTB4 synthesis preincubated for 15 mins followed by calcimycin stimulation measured after 30 mins | Mus musculus | 4 | ALA3414472 | single protein format | Scientific Literature | |
| 7. | ALA3420849 | A | Metabolic stability in human liver microsomes at 1 uM preincubated for 10 mins followed by NADPH addition measured over 60 mins by LC/MS analysis relative to hepatic blood flow | Homo sapiens | 4 | ALA3414472 | assay format | Scientific Literature | |
| 8. | ALA3420850 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 10 mins followed by NADPH addition measured after 6 mins | Homo sapiens | 4 | ALA3414472 | assay format | Scientific Literature | |
| 9. | ALA3420851 | B | Inhibition of human ERG expressed in HEK293 cells assessed as change in tail current at 11 uM by manual patch clamp assay relative to control | Homo sapiens | 4 | ALA3414472 | cell-based format | Scientific Literature |
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