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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA3424502 F Anti-Parkinson activity in human D1 receptor knock in mouse assessed as increase in basal locomotor activity by measuring total ambulations at 3 mg/kg, po measured every 10 mins for 60 mins (Rvb = 305 to 542 No_unit) Mus musculus 4 ALA3421584 organism-based format Scientific Literature 2. ALA3424503 F Anti-Parkinson activity in human D1 receptor knock in mouse assessed as increase in basal locomotor activity by measuring total ambulations at 30 mg/kg, po measured every 10 mins for 60 mins (Rvb = 305 to 542 No_unit) Mus musculus 4 ALA3421584 organism-based format Scientific Literature 3. ALA4337841 P Solubility of the compound in pH 6.0 buffer by high throughput solubility assay 3 ALA4334497 small-molecule physicochemical format Scientific Literature 4. ALA4337842 A Unbound intrinsic clearance in human liver microsomes Homo sapiens 3 ALA4334497 microsome format Scientific Literature 5. ALA4337844 F Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay Homo sapiens 3 ALA4334497 cell-based format Scientific Literature 6. ALA4337845 F Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay relative to dopamine alone Homo sapiens 3 ALA4334497 cell-based format Scientific Literature 7. ALA4337846 A Unbound intrinsic clearance in mouse liver microsomes Mus musculus 3 ALA4334497 microsome format Scientific Literature 8. ALA4337858 A Unbound fraction in mouse plasma by equilibrium dialysis assay Mus musculus 2 ALA4334497 cell-free format Scientific Literature 9. ALA4337859 A Unbound fraction in mouse brain by equilibrium dialysis assay Mus musculus 2 ALA4334497 tissue-based format Scientific Literature 10. ALA4337860 A Unbound fraction in mouse liver microsomes by equilibrium dialysis assay Mus musculus 2 ALA4334497 microsome format Scientific Literature 11. ALA4337861 A Permeability from apical to basolateral side in MDCK2 cells stably expressing human wild-type ABCB1 at 5 uM incubated for 60 mins Canis lupus familiaris 2 ALA4334497 cell-based format Scientific Literature 12. ALA4337862 A Unbound brain-to-plasma concentration ratio in mouse at 3 to 240 mg/kg, po by LC-MS/MS.analysis Mus musculus 2 ALA4334497 organism-based format Scientific Literature 13. ALA4337864 A Clearance in CD1 mouse 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS.analysis Mus musculus 2 ALA4334497 organism-based format Scientific Literature 14. ALA4337865 A Half life in CD1 mouse 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS.analysis Mus musculus 2 ALA4334497 organism-based format Scientific Literature 15. ALA4337866 A AUC in CD1 mouse 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS.analysis Mus musculus 2 ALA4334497 organism-based format Scientific Literature 16. ALA4337868 A Volume of distribution at steady state in CD1 mouse 1 mg/kg, iv or 10 mg/kg, po measured up to 24 hrs by LC-MS/MS.analysis Mus musculus 2 ALA4334497 organism-based format Scientific Literature 17. ALA4337869 A AUC in CD1 mouse 10 mg/kg, po measured up to 24 hrs by LC-MS/MS.analysis Mus musculus 2 ALA4334497 organism-based format Scientific Literature 18. ALA4337870 A Cmax in CD1 mouse 10 mg/kg, po measured up to 24 hrs by LC-MS/MS.analysis Mus musculus 2 ALA4334497 organism-based format Scientific Literature 19. ALA4337871 A Tmax in CD1 mouse 10 mg/kg, po measured up to 24 hrs by LC-MS/MS.analysis Mus musculus 2 ALA4334497 organism-based format Scientific Literature 20. ALA4337872 A Oral bioavailability in CD1 mouse 10 mg/kg measured up to 24 hrs by LC-MS/MS.analysis Mus musculus 2 ALA4334497 organism-based format Scientific Literature