| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3425138 | Binding | Inhibition of recombinant human PFKFB1 using fructose 6 phosphate as substrate assessed as ADP generation after 1 hr by ADP Glo assay | Homo sapiens | 37 | ALA3421585 | single protein format | Scientific Literature | |
| 2. | ALA3425139 | Binding | Inhibition of recombinant human PFKFB2 using fructose 6 phosphate as substrate assessed as ADP generation after 1 hr by ADP Glo assay | Homo sapiens | 37 | ALA3421585 | single protein format | Scientific Literature | |
| 3. | ALA3425140 | Binding | Inhibition of recombinant human PFKFB3 using fructose 6 phosphate as substrate assessed as ADP generation after 1 hr by ADP Glo assay | Homo sapiens | 38 | ALA3421585 | single protein format | Scientific Literature | |
| 4. | ALA3425141 | Physicochemical | Lipophilicity, log D of the compound at pH 7.4 | 35 | ALA3421585 | small-molecule physicochemical format | Scientific Literature | ||
| 5. | ALA3425231 | Binding | Inhibition of PFKFB3 in human A549 cells assessed as reduction of fructose-1,6-bisphosphate formation after 4 hrs by MS/MS analysis | Homo sapiens | 20 | ALA3421585 | cell-based format | Scientific Literature | |
| 6. | ALA3425232 | Binding | Inhibition of PFKFB3 in human A549 cells assessed as decrease in lactate secretion after 4 hrs | Homo sapiens | 32 | ALA3421585 | cell-based format | Scientific Literature | |
| 7. | ALA3425234 | Binding | Selectivity ratio of IC50 for recombinant human PFKFB2 to IC50 for recombinant human PFKFB1 | Homo sapiens | 1 | ALA3421585 | assay format | Scientific Literature | |
| 8. | ALA3425235 | Binding | Selectivity ratio of IC50 for recombinant human PFKFB3 to IC50 for recombinant human PFKFB1 | Homo sapiens | 1 | ALA3421585 | assay format | Scientific Literature |
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