# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3428605 | F | Antiviral activity against RSV A2 infected in human Hep2 cells assessed as protection against virus-induced cytopathic effect after 4 days by Cell-Titer Glo assay | Human respiratory syncytial virus A2 | 15 | ALA3425402 | cell-based format | Scientific Literature | |
2. | ALA3428606 | B | Inhibition of RSV A2 RNA-dependent RNA polymerase expressed in human Hep2 cells using ATP, GTP, UTP, CTP and 1.5 uCi [alpha-32P] NTP as substrate assessed as reduction of total radiolabled transcript after 90 mins by agarose gel electrophoresis | Human respiratory syncytial virus A2 | 15 | ALA3425402 | cell-based format | Scientific Literature | |
3. | ALA3428607 | B | Inhibition of human mitochondrial RNA polymerase using 5'-32P-R12/D18 as RNA/DNA template assessed as single nucleotide incorporation rate at 500 uM after 0.17 to 30 mins by PAGE analysis | Homo sapiens | 16 | ALA3425402 | single protein format | Scientific Literature | |
4. | ALA3428608 | B | Inhibition of human mitochondrial DNA polymerase gamma large subunit/DNA polymerase gamma accessory subunit using 32P-D19/D36 as DNA primer/template assessed as single nucleotide incorporation rate at 100 uM after 5 to 90 mins by PAGE analysis relative to thymidine NTP | Homo sapiens | 16 | ALA3425402 | protein format | Scientific Literature | |
5. | ALA3428609 | A | Cytotoxicity against human MT4 cells assessed as cell viability after 5 days by Cell-Titer Glo assay | Homo sapiens | 13 | ALA3425402 | cell-based format | Scientific Literature | |
6. | ALA4825255 | F | Antiviral activity against SARS-CoV-2 nCoV-2019BetaCoV/Wuhan/WIV04/ infected in African green monkey Vero E6 cells assessed as inhibition of viral replication at 5 uM when host cells were pretreated for 1 hr followed by viral infection then followed by removal of infected supernatant and subsequent culture addition with fresh compounds and measured after 24 hrs by qRT-PCR method relative to control | Severe acute respiratory syndrome coronavirus 2 | 22 | ALA4823313 | organism-based format | Scientific Literature |