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# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3428605 | Functional | Antiviral activity against RSV A2 infected in human Hep2 cells assessed as protection against virus-induced cytopathic effect after 4 days by Cell-Titer Glo assay | Human respiratory syncytial virus A2 | 15 | ALA3425402 | cell-based format | Scientific Literature | |
2. | ALA3428606 | Binding | Inhibition of RSV A2 RNA-dependent RNA polymerase expressed in human Hep2 cells using ATP, GTP, UTP, CTP and 1.5 uCi [alpha-32P] NTP as substrate assessed as reduction of total radiolabled transcript after 90 mins by agarose gel electrophoresis | Human respiratory syncytial virus A2 | 15 | ALA3425402 | cell-based format | Scientific Literature | |
3. | ALA3428607 | Binding | Inhibition of human mitochondrial RNA polymerase using 5'-32P-R12/D18 as RNA/DNA template assessed as single nucleotide incorporation rate at 500 uM after 0.17 to 30 mins by PAGE analysis | Homo sapiens | 16 | ALA3425402 | single protein format | Scientific Literature | |
4. | ALA3428608 | Binding | Inhibition of human mitochondrial DNA polymerase gamma large subunit/DNA polymerase gamma accessory subunit using 32P-D19/D36 as DNA primer/template assessed as single nucleotide incorporation rate at 100 uM after 5 to 90 mins by PAGE analysis relative to thymidine NTP | Homo sapiens | 16 | ALA3425402 | protein format | Scientific Literature | |
5. | ALA3428609 | ADME | Cytotoxicity against human MT4 cells assessed as cell viability after 5 days by Cell-Titer Glo assay | Homo sapiens | 13 | ALA3425402 | cell-based format | Scientific Literature |
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