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# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3428359 | Binding | Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assay | Homo sapiens | 84 | ALA3425493 | assay format | Scientific Literature | |
2. | ALA3428360 | Binding | Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysis | Mus musculus | 84 | ALA3425493 | cell-based format | Scientific Literature | |
3. | ALA3428361 | Binding | Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysis | Homo sapiens | 4 | ALA3425493 | single protein format | Scientific Literature | |
4. | ALA3428362 | ADME | Permeability across MDCK cells | Canis lupus familiaris | 11 | ALA3425493 | cell-based format | Scientific Literature | |
5. | ALA3428363 | Physicochemical | Solubility of the compound by chemiluminescent nitrogen detection method | 12 | ALA3425493 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA3428364 | ADME | Clearance in mouse at 1 mg/kg, iv using 10% DMSO:10% PEG400:80% (20% SBE-CD, citrate buffered pH 6.0) as formulation | Mus musculus | 2 | ALA3425493 | organism-based format | Scientific Literature | |
7. | ALA3428366 | ADME | Volume of distribution at steady state in mouse at 1 mg/kg, iv using 10% DMSO:10% PEG400:80% (20% SBE-CD, citrate buffered pH 6.0) as formulation | Mus musculus | 2 | ALA3425493 | organism-based format | Scientific Literature | |
8. | ALA3428370 | ADME | Terminal half life in mouse at 1 mg/kg, iv using 10% DMSO:10% PEG400:80% (20% SBE-CD, citrate buffered pH 6.0) as formulation | Mus musculus | 2 | ALA3425493 | organism-based format | Scientific Literature | |
9. | ALA3428890 | ADME | Cmax in mouse at 1 mg/kg, iv using 10% DMSO:10% PEG400:80% (20% SBE-CD, citrate buffered pH 6.0) as formulation | Mus musculus | 2 | ALA3425493 | organism-based format | Scientific Literature | |
10. | ALA3428894 | ADME | Dose normalized AUC in mouse at 1 mg/kg, iv using 10% DMSO:10% PEG400:80% (20% SBE-CD, citrate buffered pH 6.0) as formulation | Mus musculus | 2 | ALA3425493 | organism-based format | Scientific Literature | |
11. | ALA3429030 | Physicochemical | Retention time of the compound by RP-HPLC analysis | 25 | ALA3425493 | small-molecule physicochemical format | Scientific Literature |