# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3427871 | F | Cytotoxicity against human U937 cells assessed as cell death after 72 hrs by sulforhodamine B assay | Homo sapiens | 45 | cell-based format | Scientific Literature | ||
2. | ALA3427872 | A | Metabolic stability in rat liver microsomes at 10 uM after 3 hrs by LC/MS analysis | Rattus norvegicus | 45 | assay format | Scientific Literature | ||
3. | ALA3427874 | T | Toxicity in C57BL/6 mouse at 200 mg/kg, ip measured over 24 hrs | Mus musculus | 40 | organism-based format | Scientific Literature | ||
4. | ALA3427880 | P | Metal chelating activity of the compound assessed as zinc complex formation after 5 mins by EGTA fluorescence titration Assay | 7 | small-molecule physicochemical format | Scientific Literature | |||
5. | ALA3427881 | B | Activation of Caspase 3/7 in human U937 cells assessed as cleavage of Ac-DEVD-AFC at 30 uM after 16 hrs by fluorescence assay relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
6. | ALA3427883 | F | Induction of apoptosis in human U937 cells assessed as early apoptotic cells at 50 uM after 12 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 2%) | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
7. | ALA3427884 | F | Induction of apoptosis in human U937 cells assessed as late apoptotic cells at 50 uM after 12 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 2%) | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
8. | ALA3427885 | F | Induction of apoptosis in human U937 cells assessed as necrotic cells at 50 uM after 12 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric analysis relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
9. | ALA3427886 | F | Induction of apoptosis in human U937 cells assessed as viable cells at 50 uM after 12 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 96%) | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
10. | ALA3427887 | F | Cytotoxicity against human Jurkat cells assessed as cell death after 72 hrs by sulforhodamine B assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
11. | ALA3427888 | F | Cytotoxicity against dog GL1 cells assessed as cell death after 72 hrs by sulforhodamine B assay | Canis lupus familiaris | 6 | cell-based format | Scientific Literature | ||
12. | ALA3427889 | F | Cytotoxicity against dog OSW cells assessed as cell death after 72 hrs by sulforhodamine B assay | Canis lupus familiaris | 6 | cell-based format | Scientific Literature | ||
13. | ALA3427890 | F | Cytotoxicity against mouse EL4 cells assessed as cell death after 72 hrs by sulforhodamine B assay | Mus musculus | 6 | cell-based format | Scientific Literature | ||
14. | ALA3427891 | A | Drug uptake in C57/BL6 mouse serum at 25 mg/kg, iv measured after 8 hrs by LC/MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
15. | ALA3427893 | A | Elimination half life in C57/BL6 mouse at 25 mg/kg, iv and po by LC/MS/MS analysis | Mus musculus | 6 | organism-based format | Scientific Literature | ||
16. | ALA3428655 | A | AUC in C57/BL6 mouse at 25 mg/kg, iv by LC/MS/MS analysis | Mus musculus | 6 | organism-based format | Scientific Literature | ||
17. | ALA3428656 | A | AUC in C57/BL6 mouse at 25 mg/kg, po by LC/MS/MS analysis | Mus musculus | 6 | organism-based format | Scientific Literature | ||
18. | ALA3428657 | A | Oral bioavailability in C57/BL6 mouse at 25 mg/kg by LC/MS/MS analysis | Mus musculus | 6 | organism-based format | Scientific Literature |