# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3429731 | B | Inhibition of Norovirus recombinant 3CL protease using Edans-EPDFHLQGPEDLAK-Dabcyl as substrate for 30 mins by fluorometry | Norovirus | 32 | assay format | Scientific Literature | ||
2. | ALA3429732 | F | Antiviral activity against Norovirus infected in human HG23 cells | Norovirus | 32 | cell-based format | Scientific Literature | ||
3. | ALA4013952 | B | Inhibition of Norovirus 3CL protease using Edans-DFHLQ/GP-Dabcyl as substrate after 30 mins by FRET assay | Norovirus | 26 | assay format | Scientific Literature | ||
4. | ALA4013953 | F | Antiviral activity against Norovirus infected in human HG23 cells assessed as inhibition of viral replication after 48 hrs by quantitative RT-PCR method | Norovirus | 26 | cell-based format | Scientific Literature | ||
5. | ALA4013954 | F | Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
6. | ALA4013955 | T | Selectivity index, ratio of CC50 for human HG23 cells to EC50 for norovirus | 6 | assay format | Scientific Literature | |||
7. | ALA4013956 | A | Metabolic stability of human liver microsomes assessed as amount of parent compound remaining at 25 to 100 uM after 1 hr in the presence of NADPH by LC-MS method | Homo sapiens | 8 | assay format | Scientific Literature | ||
8. | ALA4013957 | A | Metabolic stability of mouse liver microsomes assessed as amount of parent compound remaining at 25 to 100 uM after 1 hr in the presence of NADPH by LC-MS method | Mus musculus | 8 | assay format | Scientific Literature | ||
9. | ALA4013958 | A | Protein binding in human serum at 25 to 100 uM after 4 hrs by LC-MS method | Homo sapiens | 8 | cell-free format | Scientific Literature | ||
10. | ALA4013959 | A | Protein binding in mouse serum at 25 to 100 uM after 4 hrs by LC-MS method | Mus musculus | 8 | cell-free format | Scientific Literature | ||
11. | ALA4013961 | A | Metabolic stability in human serum assessed as amount of parent compound remaining at 25 to 100 uM at 37 degC after 1 hr by LC-MS analysis | Homo sapiens | 5 | cell-free format | Scientific Literature | ||
12. | ALA4013962 | A | Metabolic stability in mouse serum assessed as amount of parent compound remaining at 25 to 100 uM at 37 degC after 1 hr by LC-MS analysis | Mus musculus | 5 | cell-free format | Scientific Literature | ||
13. | ALA4827057 | B | Inhibition of SARS CoV-2 main protease expressed in Escherichia coli BL21 (DE3) using Abz-SVTLQSG-Y(NO2)-R as substrate by FRET based assay | Severe acute respiratory syndrome coronavirus 2 | 22 | assay format | Scientific Literature | ||
14. | ALA4827058 | F | Antiviral activity against SARS-CoV-2 infected in African Green monkey Vero E6 cells assessed as reduction in viral plaques incubated for 48 hrs by quantitative RT-PCR assay | Severe acute respiratory syndrome coronavirus 2 | 22 | organism-based format | Scientific Literature | ||
15. | ALA4827059 | F | Antiviral activity against SARS-CoV-2 infected in African Green monkey Vero E6 cells assessed as reduction in viral plaques in presence of efflux inhibitor CP-100356 incubated for 48 hrs by quantitative RT-PCR assay | Severe acute respiratory syndrome coronavirus 2 | 22 | organism-based format | Scientific Literature | ||
16. | ALA4827060 | A | Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability after 24 hrs by CellTiter-Glo luminescent cell viability assay | Chlorocebus sabaeus | 22 | cell-based format | Scientific Literature | ||
17. | ALA5030359 | B | Inhibition of SARS CoV-2 3C like protease expressed in HEK293T cells transfected with pGlo-VRLQS incubated for 6 hrs by firefly/renilla luciferase reporter assay | Severe acute respiratory syndrome coronavirus 2 | 49 | cell-based format | Scientific Literature | ||
18. | ALA5030360 | F | Antiviral activity against SARS CoV-2 infected in African green monkey Vero cells assessed as inhibition of viral replication incubated for 48 to 72 hrs by plaque reduction assay | Severe acute respiratory syndrome coronavirus 2 | 3 | organism-based format | Scientific Literature | ||
19. | ALA5030362 | T | Selectivity index, ratio of EC50 for inhibition of SARS CoV-2 3C like protease expressed in HEK293T cells transfected with pGlo-VRLQS incubated for 6 hrs by firefly/renilla luciferase reporter assay to EC50 for antiviral activity against SARS CoV-2 infected in African green monkey Vero cells assessed as inhibition of viral replication incubated for 48 to 72 hrs by plaque reduction assay | 3 | cell-based format | Scientific Literature | |||
20. | ALA5039262 | B | Inhibition of SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 DE3 using Abz-SVTLQSG-Tyr(NO2)-R as fluorogenic substrate incubated for 10 mins by FRET assay | Severe acute respiratory syndrome coronavirus 2 | 1 | assay format | Scientific Literature |