# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3430052 | B | Displacement of [3H]TBPS from GABAA receptor in Sprague-Dawley rat brain cortical membrane after 90 mins by liquid scintillation spectrometry | Rattus norvegicus | 32 | ALA3425450 | assay format | Scientific Literature | |
2. | ALA3430053 | B | Positive allosteric modulation of recombinant alpha1beta2gamma2 GABAA receptor (unknown origin) expressed in LTK cells assessed as potentiation of GABA-induced channel current treated for 30 s prior to GABA stimulation for 2s by Q-patch assay | Homo sapiens | 30 | ALA3425450 | cell-based format | Scientific Literature | |
3. | ALA3430055 | P | Lipophilicity, log D of the compound at 20 uM at pH 7.4 by HPLC-MS/MS analysis | 9 | ALA3425450 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA3430056 | P | Aqueous solubility of the compound at pH 7.4 by HPLC-MS/MS analysis | 9 | ALA3425450 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA3427973 | A | Clearance in human liver microsomes at 10 uM after 60 mins by HPLC-MS/MS analysis | Homo sapiens | 9 | ALA3425450 | assay format | Scientific Literature | |
6. | ALA3427974 | A | Clearance in rat liver microsomes at 10 uM after 60 mins by HPLC-MS/MS analysis | Rattus norvegicus | 9 | ALA3425450 | assay format | Scientific Literature | |
7. | ALA3427975 | A | Clearance in mouse liver microsomes at 10 uM after 60 mins by HPLC-MS/MS analysis | Mus musculus | 9 | ALA3425450 | assay format | Scientific Literature | |
8. | ALA3427976 | A | Clearance in Sprague-Dawley rat at 5 mg/kg, iv and 20 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 7 | ALA3425450 | organism-based format | Scientific Literature | |
9. | ALA3427977 | A | Oral bioavailability in Sprague-Dawley rat at 20 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 7 | ALA3425450 | organism-based format | Scientific Literature | |
10. | ALA3427978 | A | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 5 mg/kg, iv after 30 mins by LC-MS/MS analysis | Rattus norvegicus | 7 | ALA3425450 | organism-based format | Scientific Literature | |
11. | ALA3427979 | P | Retention time of the compound by LC-MS analysis | 28 | ALA3425450 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA3427980 | B | Positive allosteric modulation of recombinant alpha4beta3delta GABAA receptor (unknown origin) expressed in CHO cells assessed as potentiation of GABA-induced channel current treated for 30 s prior to GABA stimulation for 2s by manual patch assay | Homo sapiens | 30 | ALA3425450 | cell-based format | Scientific Literature | |
13. | ALA4040853 | B | Displacement of [35S]TBPS from GABA-A receptor in Sprague-Dawley rat cerebral cortex cell membranes after 90 mins in presence of GABA by liquid scintillation counting | Rattus norvegicus | 21 | ALA4038335 | assay format | Scientific Literature | |
14. | ALA4040854 | B | Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-mediated increase in channel current under holding potential at -80 mV preincubated for 30 secs followed by GABA stimulation for 2 secs by automated patch clamp assay | Homo sapiens | 21 | ALA4038335 | cell-based format | Scientific Literature | |
15. | ALA4040855 | B | Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-mediated increase in channel current under holding potential at -80 mV at 0.01 to 10 uM preincubated for 30 secs followed by GABA stimulation for 2 secs by automated patch clamp assay relative to GABA | Homo sapiens | 21 | ALA4038335 | cell-based format | Scientific Literature | |
16. | ALA4040856 | B | Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated increase in channel current under holding potential at -80 mV preincubated for 30 secs followed by GABA stimulation for 2 secs by manual patch clamp assay | Homo sapiens | 21 | ALA4038335 | cell-based format | Scientific Literature | |
17. | ALA4040857 | B | Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated increase in channel current under holding potential at -80 mV at 0.01 to 10 uM preincubated for 30 secs followed by GABA stimulation for 2 secs by manual patch clamp assay relative to GABA | Homo sapiens | 21 | ALA4038335 | cell-based format | Scientific Literature | |
18. | ALA4040858 | P | Lipophilicity, logD of compound at 20 uM at pH 7.4 by HPLC/MS-MS analysis | 7 | ALA4038335 | small-molecule physicochemical format | Scientific Literature | ||
19. | ALA4040859 | P | Thermodynamic aqueous solubility of compound at 10 uM sonicated for 1 min followed by incubation for 1 hr by HPLC-MS/MS | 7 | ALA4038335 | small-molecule physicochemical format | Scientific Literature | ||
20. | ALA4040860 | A | Clearance in human hepatic microsomes at 10 uM preincubated for 5 mins followed by NADPH addition measured over 60 mins by HPLC-MS/MS analysis | Homo sapiens | 7 | ALA4038335 | assay format | Scientific Literature |