# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3430052 | B | Displacement of [3H]TBPS from GABAA receptor in Sprague-Dawley rat brain cortical membrane after 90 mins by liquid scintillation spectrometry | Rattus norvegicus | 32 | ALA3425450 | assay format | Scientific Literature | |
2. | ALA3430053 | B | Positive allosteric modulation of recombinant alpha1beta2gamma2 GABAA receptor (unknown origin) expressed in LTK cells assessed as potentiation of GABA-induced channel current treated for 30 s prior to GABA stimulation for 2s by Q-patch assay | Homo sapiens | 30 | ALA3425450 | cell-based format | Scientific Literature | |
3. | ALA3430055 | P | Lipophilicity, log D of the compound at 20 uM at pH 7.4 by HPLC-MS/MS analysis | 9 | ALA3425450 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA3430056 | P | Aqueous solubility of the compound at pH 7.4 by HPLC-MS/MS analysis | 9 | ALA3425450 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA3427973 | A | Clearance in human liver microsomes at 10 uM after 60 mins by HPLC-MS/MS analysis | Homo sapiens | 9 | ALA3425450 | assay format | Scientific Literature | |
6. | ALA3427974 | A | Clearance in rat liver microsomes at 10 uM after 60 mins by HPLC-MS/MS analysis | Rattus norvegicus | 9 | ALA3425450 | assay format | Scientific Literature | |
7. | ALA3427975 | A | Clearance in mouse liver microsomes at 10 uM after 60 mins by HPLC-MS/MS analysis | Mus musculus | 9 | ALA3425450 | assay format | Scientific Literature | |
8. | ALA3427979 | P | Retention time of the compound by LC-MS analysis | 28 | ALA3425450 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA3427980 | B | Positive allosteric modulation of recombinant alpha4beta3delta GABAA receptor (unknown origin) expressed in CHO cells assessed as potentiation of GABA-induced channel current treated for 30 s prior to GABA stimulation for 2s by manual patch assay | Homo sapiens | 30 | ALA3425450 | cell-based format | Scientific Literature |