| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3539596 | A | Prodrug conversion in human liver microsomes assessed as elution time at 10 uM after 180 mins incubation by HPLC-UV chromatography | Homo sapiens | 1 | ALA3525966 | assay format | Scientific Literature | |
| 2. | ALA3539597 | A | Prodrug conversion in human liver microsomes assessed as depletion of compound at 10 uM after 180 mins incubation by HPLC-UV chromatography | Homo sapiens | 1 | ALA3525966 | assay format | Scientific Literature | |
| 3. | ALA3536990 | A | Prodrug conversion in rat liver microsomes assessed as depletion of compound at 10 uM after 180 mins incubation by HPLC-UV chromatography | Rattus norvegicus | 1 | ALA3525966 | assay format | Scientific Literature | |
| 4. | ALA3536994 | A | Drug metabolism in human liver microsomes assessed as (Z)-6-(5-(5-carbamimidoylpyridin-2-yl)furan-2-yl)-N'-hydroxynicotinimidamide formation treated at 10 uM after 180 mins incubation by HPLC-UV chromatogram relative to initial prodrug concentration | Homo sapiens | 1 | ALA3525966 | assay format | Scientific Literature | |
| 5. | ALA3536995 | A | Drug metabolism in rat liver microsomes assessed as (Z)-6-(5-(5-carbamimidoylpyridin-2-yl)furan-2-yl)-N'-hydroxynicotinimidamide formation treated at 10 uM after 180 mins incubation by HPLC-UV chromatogram relative to initial prodrug concentration | Rattus norvegicus | 1 | ALA3525966 | assay format | Scientific Literature | |
| 6. | ALA3536996 | A | Prodrug conversion in human liver microsomes assessed as DB829 compound formation treated at 10 uM after 180 mins incubation by HPLC-UV chromatography relative to initial prodrug concentration | Homo sapiens | 1 | ALA3525966 | assay format | Scientific Literature | |
| 7. | ALA3536997 | A | Prodrug conversion assessed as human recombinant CYP1A2-mediated (Z)-N'-hydroxy-6-(5-(5-((Z)-N'-methoxycarbamimidoyl)pyridin-2-yl)furan-2-yl) nicotinimidamide formation at 5 uM after 180 mins incubation by HPLC-UV chromatogram | Homo sapiens | 1 | ALA3525966 | single protein format | Scientific Literature | |
| 8. | ALA3536998 | A | Prodrug conversion assessed as human recombinant CYP3A4-mediated (Z)-N'-hydroxy-6-(5-(5-((Z)-N'-methoxycarbamimidoyl)pyridin-2-yl)furan-2-yl) nicotinimidamide formation at 5 uM after 180 mins incubation by HPLC-UV chromatogram | Homo sapiens | 1 | ALA3525966 | single protein format | Scientific Literature | |
| 9. | ALA3537358 | A | Prodrug conversion assessed as human recombinant CYP4F2-mediated (Z)-N'-hydroxy-6-(5-(5-((Z)-N'-methoxycarbamimidoyl)pyridin-2-yl)furan-2-yl) nicotinimidamide formation at 5 uM after 180 mins incubation by HPLC-UV chromatogram | Homo sapiens | 1 | ALA3525966 | single protein format | Scientific Literature | |
| 10. | ALA3537359 | A | Prodrug conversion assessed as human recombinant CYP1A2-mediated (3Z,3'Z)-6,6'-(furan-2,5-diyl)bis(N'-hydroxynicotinimidamide) formation at 5 uM after 180 mins incubation by HPLC-UV chromatogram | Homo sapiens | 1 | ALA3525966 | single protein format | Scientific Literature | |
| 11. | ALA3537362 | A | Prodrug conversion assessed as rat recombinant CYP1A2-mediated (Z)-N'-hydroxy-6-(5-(5-((Z)-N'-methoxycarbamimidoyl)pyridin-2-yl)furan-2-yl) nicotinimidamide formation at 5 uM after 180 mins incubation by HPLC-UV chromatogram | Rattus norvegicus | 1 | ALA3525966 | single protein format | Scientific Literature | |
| 12. | ALA3537363 | A | Prodrug conversion assessed as rat recombinant CYP2D2-mediated (Z)-N'-hydroxy-6-(5-(5-((Z)-N'-methoxycarbamimidoyl)pyridin-2-yl)furan-2-yl) nicotinimidamide formation at 5 uM after 180 mins incubation by HPLC-UV chromatogram | Rattus norvegicus | 1 | ALA3525966 | single protein format | Scientific Literature | |
| 13. | ALA3537364 | A | Prodrug conversion assessed as rat recombinant CYP4F1-mediated (Z)-N'-hydroxy-6-(5-(5-((Z)-N'-methoxycarbamimidoyl)pyridin-2-yl)furan-2-yl) nicotinimidamide formation at 5 uM after 180 mins incubation by HPLC-UV chromatogram | Rattus norvegicus | 1 | ALA3525966 | single protein format | Scientific Literature | |
| 14. | ALA3537365 | A | Prodrug conversion assessed as rat recombinant CYP1A2-mediated (3Z,3'Z)-6,6'-(furan-2,5-diyl)bis(N'-hydroxynicotinimidamide) formation at 5 uM after 180 mins incubation by HPLC-UV chromatogram | Rattus norvegicus | 1 | ALA3525966 | single protein format | Scientific Literature | |
| 15. | ALA3536074 | A | Drug metabolism in rat recombinant CYP2C13 assessed as (Z)-N'-hydroxy-6-(5-(5-((Z)-N'-methoxycarbamimidoyl)pyridin-2-yl)furan-2-yl nicotinimidamide formation treated with DB868 | Rattus norvegicus | 1 | ALA3525966 | assay format | Scientific Literature | |
| 16. | ALA3536075 | A | Drug metabolism in rat recombinant CYP2C13 assessed as (3Z,3'Z)-6,6'-(furan-2,5-diyl)bis(N'-hydroxynicotinimidamide) formation treated with DB868 | Rattus norvegicus | 1 | ALA3525966 | assay format | Scientific Literature | |
| 17. | ALA3536076 | A | Drug metabolism in rat recombinant CYP2D1 assessed as (Z)-N'-hydroxy-6-(5-(5-((Z)-N'-methoxycarbamimidoyl)pyridin-2-yl)furan-2-yl nicotinimidamide formation treated with DB868 | Rattus norvegicus | 1 | ALA3525966 | assay format | Scientific Literature | |
| 18. | ALA3536077 | A | Drug metabolism in rat recombinant CYP2D1 assessed as (3Z,3'Z)-6,6'-(furan-2,5-diyl)bis(N'-hydroxynicotinimidamide) formation treated with DB868 | Rattus norvegicus | 1 | ALA3525966 | assay format | Scientific Literature | |
| 19. | ALA3536078 | A | Drug metabolism in human recombinant CYP2E1 assessed as (Z)-N'-hydroxy-6-(5-(5-((Z)-N'-methoxycarbamimidoyl)pyridin-2-yl)furan-2-yl nicotinimidamide formation treated with DB868 | Homo sapiens | 1 | ALA3525966 | single protein format | Scientific Literature | |
| 20. | ALA3536079 | A | Drug metabolism in rat recombinant CYP2E1 assessed as (Z)-N'-hydroxy-6-(5-(5-((Z)-N'-methoxycarbamimidoyl)pyridin-2-yl)furan-2-yl nicotinimidamide formation treated with DB868 | Rattus norvegicus | 1 | ALA3525966 | assay format | Scientific Literature |
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