Drug level in cynomolgus monkey plasma assessed as compound formation treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage measured after 12 hrs by mass spectrometry
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 1 hr by mass spectrometry
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 2 hrs by mass spectrometry
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 4 hrs by mass spectrometry
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 8 hrs by mass spectrometry
Drug level in human plasma assessed as compound formation treated with [14C]brivanib alaninate at 800 mg, po administered as single dose via gavage measured after 12 hrs by mass spectrometry
Drug level in bile duct-cannulated rat bile treated with [14C]brivanib alaninate at 100 mg/kg, po administered as single dose via gavage by mass spectrometry
Drug level in bile duct-cannulated cynomolgus monkey bile treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage by mass spectrometry
Drug excretion in Sprague-Dawley rat urine treated with [14C]brivanib alaninate at 100 mg/kg, po administered as single dose via gavage by HPLC analysis
Drug excretion in Sprague-Dawley rat feces treated with [14C]brivanib alaninate at 100 mg/kg, po administered as single dose via gavage by HPLC analysis
Drug level in Sprague-Dawley rat plasma assessed as compound formation treated with [14C]brivanib alaninate at 100 mg/kg, po administered as single dose via gavage measured after 1 hr by mass spectrometry
Drug level in Sprague-Dawley rat plasma assessed as compound formation treated with [14C]brivanib alaninate at 100 mg/kg, po administered as single dose via gavage measured after 2 hrs by mass spectrometry
Drug level in Sprague-Dawley rat plasma assessed as compound formation treated with [14C]brivanib alaninate at 100 mg/kg, po administered as single dose via gavage measured after 6 hrs by mass spectrometry
Drug level in cynomolgus monkey plasma assessed as compound formation treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage measured after 1 hr by mass spectrometry
Drug level in cynomolgus monkey plasma assessed as compound formation treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage measured after 2 hrs by mass spectrometry
Drug level in cynomolgus monkey plasma assessed as compound formation treated with [14C]brivanib alaninate at 10 mg/kg, po administered as single dose via gavage measured after 4 hrs by mass spectrometry