| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3538229 | A | Activity of recombinant human CYP2D6 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis | Homo sapiens | 8 | ALA3526051 | assay format | Scientific Literature | |
| 2. | ALA3538231 | A | Activity of recombinant human CYP2E1 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis | Homo sapiens | 4 | ALA3526051 | assay format | Scientific Literature | |
| 3. | ALA3538471 | A | Activity of recombinant human CYP3A4 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis | Homo sapiens | 5 | ALA3526051 | assay format | Scientific Literature | |
| 4. | ALA3538473 | A | Activity of recombinant human CYP3A4 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis in presence of cytochrome b5 | Homo sapiens | 5 | ALA3526051 | assay format | Scientific Literature | |
| 5. | ALA3538475 | A | Activity of recombinant human CYP3A5 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis | Homo sapiens | 5 | ALA3526051 | assay format | Scientific Literature | |
| 6. | ALA3538477 | A | Activity of recombinant human CYP4A11 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis | Homo sapiens | 3 | ALA3526051 | assay format | Scientific Literature | |
| 7. | ALA3538479 | A | Drug metabolism in Escherichia coli JM109 assessed as compound remaining treated with LBH589 measured after 1 hr by LC-MS analysis | Escherichia coli | 3 | ALA3526051 | organism-based format | Scientific Literature | |
| 8. | ALA3538484 | B | Inhibition of HDAC1 (unknown origin) expressed in HEK293 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting | Homo sapiens | 5 | ALA3526051 | cell-based format | Scientific Literature | |
| 9. | ALA3538485 | B | Inhibition of flag-tagged HDAC2 (unknown origin) expressed in SF21 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting | Homo sapiens | 5 | ALA3526051 | cell-based format | Scientific Literature | |
| 10. | ALA3538486 | B | Inhibition of HDAC3 (unknown origin) expressed in HEK293 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting | Homo sapiens | 5 | ALA3526051 | cell-based format | Scientific Literature | |
| 11. | ALA3538487 | B | Inhibition of HDAC4 (unknown origin) expressed in HEK293 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting | Homo sapiens | 5 | ALA3526051 | cell-based format | Scientific Literature | |
| 12. | ALA3538488 | B | Inhibition of HDAC6 (unknown origin) expressed in HEK293 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting | Homo sapiens | 5 | ALA3526051 | cell-based format | Scientific Literature | |
| 13. | ALA3538489 | B | Inhibition of his-strep-tagged HDAC8 (unknown origin) expressed in SF9 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting | Homo sapiens | 5 | ALA3526051 | cell-based format | Scientific Literature | |
| 14. | ALA3538491 | A | Activity of recombinant human CYP2B6 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis | Homo sapiens | 3 | ALA3526051 | assay format | Scientific Literature | |
| 15. | ALA3539820 | A | Activity of recombinant human CYP1A1 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis | Homo sapiens | 6 | ALA3526051 | assay format | Scientific Literature | |
| 16. | ALA3537628 | A | Activity of recombinant human CYP1A2 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis | Homo sapiens | 6 | ALA3526051 | assay format | Scientific Literature | |
| 17. | ALA3537630 | A | Activity of recombinant human CYP1B1 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis | Homo sapiens | 4 | ALA3526051 | assay format | Scientific Literature | |
| 18. | ALA3537632 | A | Activity of recombinant human CYP2A6 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis | Homo sapiens | 5 | ALA3526051 | assay format | Scientific Literature | |
| 19. | ALA3537634 | A | Activity of recombinant human CYP2C8 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis | Homo sapiens | 3 | ALA3526051 | assay format | Scientific Literature | |
| 20. | ALA3537636 | A | Activity of recombinant human CYP2C9 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis | Homo sapiens | 5 | ALA3526051 | assay format | Scientific Literature |
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