| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3535636 | A | Drug level in human hepatic microsomes treated with 100 uM of [14C]Sipoglitazar after 4 hrs by HPLC analysis in presence of UDPGA | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 2. | ALA3535637 | P | Chemical stability of the compound in acetate buffer at pH 4.4 at 10 uM up to 4 hrs | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA3535638 | P | Chemical stability of the compound in potassium phosphate buffer at pH 7.4 assessed as formation of alpha-2-O-acyl glucuronide conjugate of sipoglitazar at 10 uM up to 4 hrs | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA3535957 | P | Chemical stability of the compound in potassium phosphate buffer at pH 7.4 assessed as formation of sipoglitazar at 10 uM up to 4 hrs | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA3535958 | A | Stability of the compound in rat bile assessed as formation of alpha-2-O-acyl glucuronide conjugate of sipoglitazar at 10 uM up to 4 hrs | Rattus norvegicus | 1 | tissue-based format | Scientific Literature | ||
| 6. | ALA3535959 | A | Stability of the compound in rat bile assessed as formation of sipoglitazar at 10 uM up to 4 hrs | Rattus norvegicus | 2 | tissue-based format | Scientific Literature | ||
| 7. | ALA3535960 | A | Stability of the compound in human plasma assessed as formation of alpha-2-O-acyl glucuronide conjugate of sipoglitazar at 10 uM up to 4 hrs | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 8. | ALA3535961 | A | Stability of the compound in human plasma assessed as formation of sipoglitazar at 10 uM up to 4 hrs | Homo sapiens | 2 | cell-free format | Scientific Literature | ||
| 9. | ALA3535962 | A | Drug metabolism in human hepatic microsomes assessed as formation of sipoglitazar at 10 uM after 10 mins by HPLC analysis in presence of NADPH | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 10. | ALA3535963 | A | Drug metabolism in human hepatic microsomes assessed as formation of 3-(3-hydroxy-1-{4-[(2-phenyl-1,3-thiazol-4-yl)methoxy]benzyl}-1H-pyrazol-4-yl)propanoic acid at 10 uM after 10 mins by HPLC analysis in presence of NADPH | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA3535964 | A | Drug metabolism in human hepatic microsomes assessed as CYP2C8-mediated formation of 3-(3-hydroxy-1-{4-[(2-phenyl-1,3-thiazol-4-yl)methoxy]benzyl}-1H-pyrazol-4-yl)propanoic acid at 10 uM after 15 mins by HPLC analysis in presence of NADPH | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA3535965 | A | Drug metabolism in human hepatic microsomes assessed as CYP2B6-mediated formation of 3-(3-hydroxy-1-{4-[(2-phenyl-1,3-thiazol-4-yl)methoxy]benzyl}-1H-pyrazol-4-yl)propanoic acid at 10 uM after 15 mins by HPLC analysis in presence of NADPH | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 13. | ALA3535966 | A | Drug metabolism in human hepatic microsomes assessed as CYP2E1-mediated formation of 3-(3-hydroxy-1-{4-[(2-phenyl-1,3-thiazol-4-yl)methoxy]benzyl}-1H-pyrazol-4-yl)propanoic acid at 10 uM after 15 mins by HPLC analysis in presence of NADPH | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA3535970 | A | Drug metabolism in human hepatic microsomes assessed as increase of beta-1-O-acyl glucuronide conjugate of sipoglitazar formation at 10 uM after 30 mins by LC-MS and LC-MS/MS analysis in presence of 10 uM of gemfibrozil, NADPH and UDPGA | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA3535971 | A | Drug metabolism in human hepatic microsomes assessed as increase of beta-1-O-acyl glucuronide conjugate of sipoglitazar formation at 10 uM after 30 mins by LC-MS and LC-MS/MS analysis in presence of 30 uM of gemfibrozil, NADPH and UDPGA | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 16. | ALA3535972 | A | Drug metabolism in human hepatic microsomes assessed as increase of beta-1-O-acyl glucuronide conjugate of sipoglitazar formation at 10 uM after 30 mins by LC-MS and LC-MS/MS analysis in presence of 100 uM of gemfibrozil, NADPH and UDPGA | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 17. | ALA3535973 | A | Drug metabolism in human hepatic microsomes assessed as increase of beta-1-O-acyl glucuronide conjugate of sipoglitazar formation at 10 uM after 30 mins by LC-MS and LC-MS/MS analysis in presence of 300 uM of gemfibrozil, NADPH and UDPGA | Homo sapiens | 1 | assay format | Scientific Literature |
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