Cmax as total radioactivity in cynomolgus monkey plasma treated at 10 mg/kg, po administered as single dose via gavage by liquid scintillation counting
Tmax of total radioactivity in cynomolgus monkey plasma treated at 10 mg/kg, po administered as single dose via gavage by liquid scintillation counting
AUC (0 to t) as total radioactivity in cynomolgus monkey plasma treated at 10 mg/kg, po administered as single dose via gavage by liquid scintillation counting
Drug metabolism in human liver cytosol assessed as (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propane-2-sulfonic acid formation at 2 uM for 2 hrs by LC/MS analysis in presence of PAPS
Drug recovery in Sprague-Dawley rat urine at 100 mg/kg, po administered as single dose via gavage measured during 0 to 168 hrs by liquid scintillation counting
Drug recovery in Sprague-Dawley rat feces at 100 mg/kg, po administered as single dose via gavage measured during 0 to 168 hrs by liquid scintillation counting
Total drug recovery in Sprague-Dawley rat at 100 mg/kg, po administered as single dose via gavage measured during 0 to 168 hrs by liquid scintillation counting
Drug recovery in bile duct-cannulated rat urine at 100 mg/kg, po administered as single dose via gavage measured during 0 to 48 hrs by liquid scintillation counting
Drug recovery in bile duct-cannulated rat bile at 100 mg/kg, po administered as single dose via gavage measured during 0 to 48 hrs by liquid scintillation counting
Drug recovery in bile duct-cannulated rat feces at 100 mg/kg, po administered as single dose via gavage measured during 0 to 48 hrs by liquid scintillation counting
Total drug recovery in bile duct-cannulated rat at 100 mg/kg, po administered as single dose via gavage measured during 0 to 48 hrs by liquid scintillation counting
Drug recovery in cynomolgus monkey urine at 10 mg/kg, po administered as single dose via gavage measured during 0 to 168 hrs by liquid scintillation counting
Drug recovery in cynomolgus monkey feces at 10 mg/kg, po administered as single dose via gavage measured during 0 to 168 hrs by liquid scintillation counting
Total drug recovery in cynomolgus monkey at 10 mg/kg, po administered as single dose via gavage measured during 0 to 168 hrs by liquid scintillation counting