# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3534704 | ADME | Activity of recombinant human CYP2C9 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated compound formation treated with montelukast at 1 uM after 60 mins by LC-MS analysis | Homo sapiens | 2 | ALA3525951 | assay format | Scientific Literature | |
2. | ALA3534708 | ADME | Activity of recombinant human CYP2C8 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated compound formation treated with montelukast at 0.02 to 0.1 uM after 3 mins by LC-MS analysis | Homo sapiens | 2 | ALA3525951 | assay format | Scientific Literature | |
3. | ALA3535043 | ADME | Activity of recombinant human CYP2C9 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated compound formation treated with montelukast at 0.02 to 0.1 uM after 12 mins by LC-MS analysis | Homo sapiens | 1 | ALA3525951 | assay format | Scientific Literature | |
4. | ALA3535050 | ADME | Activity of recombinant human CYP2C8 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-(2-((R)-3-((1-(carboxymethyl)cyclopropyl)methylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)phenyl)-2-hydroxypropanoic acid formation at 0.02 uM after 30 mins by LC-MS analysis | Homo sapiens | 1 | ALA3525951 | assay format | Scientific Literature | |
5. | ALA3535829 | ADME | Activity of recombinant human CYP2C9 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-(2-((R)-3-((1-(carboxymethyl)cyclopropyl)methylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)phenyl)-2-hydroxypropanoic acid formation at 0.02 uM after 30 mins by LC-MS analysis | Homo sapiens | 1 | ALA3525951 | assay format | Scientific Literature | |
6. | ALA3535830 | ADME | Activity of recombinant human CYP3A4 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-(2-((R)-3-((1-(carboxymethyl)cyclopropyl)methylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)phenyl)-2-hydroxypropanoic acid formation at 0.02 uM after 30 mins by LC-MS analysis | Homo sapiens | 1 | ALA3525951 | assay format | Scientific Literature | |
7. | ALA3536190 | ADME | Activity of recombinant human CYP1A2 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-(2-((R)-3-((1-(carboxymethyl)cyclopropyl)methylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)phenyl)-2-hydroxypropanoic acid formation at 1 uM after 30 mins by LC-MS analysis | Homo sapiens | 1 | ALA3525951 | assay format | Scientific Literature | |
8. | ALA3536191 | ADME | Activity of recombinant human CYP2A6 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-(2-((R)-3-((1-(carboxymethyl)cyclopropyl)methylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)phenyl)-2-hydroxypropanoic acid formation at 1 uM after 30 mins by LC-MS analysis | Homo sapiens | 1 | ALA3525951 | assay format | Scientific Literature | |
9. | ALA3536192 | ADME | Activity of recombinant human CYP2B6 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-(2-((R)-3-((1-(carboxymethyl)cyclopropyl)methylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)phenyl)-2-hydroxypropanoic acid formation at 1 uM after 30 mins by LC-MS analysis | Homo sapiens | 1 | ALA3525951 | assay format | Scientific Literature | |
10. | ALA3536193 | ADME | Activity of recombinant human CYP2C19 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-(2-((R)-3-((1-(carboxymethyl)cyclopropyl)methylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)phenyl)-2-hydroxypropanoic acid formation at 1 uM after 30 mins by LC-MS analysis | Homo sapiens | 1 | ALA3525951 | assay format | Scientific Literature | |
11. | ALA3536194 | ADME | Activity of recombinant human CYP2D6 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-(2-((R)-3-((1-(carboxymethyl)cyclopropyl)methylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)phenyl)-2-hydroxypropanoic acid formation at 1 uM after 30 mins by LC-MS analysis | Homo sapiens | 1 | ALA3525951 | assay format | Scientific Literature | |
12. | ALA3536195 | ADME | Activity of recombinant human CYP2E1 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-(2-((R)-3-((1-(carboxymethyl)cyclopropyl)methylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)phenyl)-2-hydroxypropanoic acid formation at 1 uM after 30 mins by LC-MS analysis | Homo sapiens | 1 | ALA3525951 | assay format | Scientific Literature | |
13. | ALA3536196 | ADME | Activity of recombinant human CYP3A5 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-(2-((R)-3-((1-(carboxymethyl)cyclopropyl)methylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)phenyl)-2-hydroxypropanoic acid formation at 1 uM after 30 mins by LC-MS analysis | Homo sapiens | 1 | ALA3525951 | assay format | Scientific Literature | |
14. | ALA3533927 | ADME | Activity of recombinant human CYP2C8 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated compound formation treated with montelukast at 0.02 to 1 uM after 60 mins by LC-MS analysis | Homo sapiens | 2 | ALA3525951 | assay format | Scientific Literature | |
15. | ALA3529512 | ADME | Drug level in human liver microsomes treated with montelukast at 0.02 to 0.4 uM preincubated for 3 mins followed by beta-NADPH addition by LC-MS analysis | Homo sapiens | 5 | ALA3525951 | assay format | Scientific Literature |